NLRP4 Antibody

Datasheet

Code	CSB-PA123062
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA123062(NLRP4 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA123062(NLRP4 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q96MN2

Target Names

NLRP4

Alternative Names

Cancer/testis antigen 58 antibody; CLR19.5 antibody; CT58 antibody; FLJ32126 antibody; NACHT, leucine rich repeat and PYD containing 4 antibody; NACHT, LRR and PYD containing protein 4 antibody; NACHT, LRR and PYD domains-containing protein 4 antibody; NALP4_HUMAN antibody; NLR family, pyrin domain containing 4 antibody; NLRP4 antibody; Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 4 antibody; PAAD and NACHT containing protein 2 antibody; PAAD and NACHT-containing protein 2 antibody; PAN2 antibody; PYPAF4 antibody; PYRIN and NACHT-containing protein 2 antibody; PYRIN containing APAF1 like protein 4 antibody; PYRIN-containing APAF1-like protein 4 antibody; Ribonuclease inhibitor 2 antibody; RNH2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide of Human NLRP4

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.

Gene References into Functions

NLRP4 is an important mediator of cardiac remodeling in vitro and in vivo. PMID: 28486191
This study describes conformational stability of native NLRP14 and mutants in their monomeric and dimeric states and compares them to NLRP4, a representative of a native pyrin domain fold. PMID: 25403012
Structural and functional analysis of the NLRP4 pyrin domain. PMID: 22928810
Our results provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation. PMID: 22388039
NLRP4 is recruited to and accumulates in bacteria-containing phagosomes and transiently dissociates from beclin1 following group A streptococcus infection, thereby controlling the autophagic flux crucial for cell-autonomous antibacterial resistance. PMID: 21209283

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Protein Families

NLRP family

Database Links

HGNC: 22943

OMIM: 609645

KEGG: hsa:147945

STRING: 9606.ENSP00000301295

UniGene: Hs.631533

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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