NOS1AP Antibody

Code CSB-PA015942LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA015942LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA015942LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA015942LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NOS1AP Polyclonal antibody
Uniprot No.
Target Names
NOS1AP
Alternative Names
6330408P19Rik antibody; C terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON) antibody; C terminal PDZ domain ligand of neuronal nitric oxide synthase antibody; C terminal PDZ ligand of neuronal nitric oxide synthase protein antibody; C-terminal PDZ ligand of neuronal nitric oxide synthase protein antibody; CAPON antibody; CAPON_HUMAN antibody; Carboxyl terminal PDZ ligand of neuronal nitric oxide synthase protein antibody; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein antibody; Ligand of neuronal nitric oxide synthase with carboxyl terminal PDZ domain antibody; MGC138500 antibody; Nitric oxide synthase 1 (neuronal) adaptor protein antibody; Nitric oxide synthase 1 adaptor protein antibody; Nos1ap antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (176-288AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The NOS1AP Antibody (Product code: CSB-PA015942LA01HU) is Non-conjugated. For NOS1AP Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA015942LB01HU NOS1AP Antibody, HRP conjugated ELISA
FITC CSB-PA015942LC01HU NOS1AP Antibody, FITC conjugated
Biotin CSB-PA015942LD01HU NOS1AP Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4.
Gene References into Functions
  1. Findings showed that NOS1AP (rs348624, rs12742393 and rs1415263), DISC1 (rs821633 and rs1000731), DAOA (rs2391191) and GSK3B (rs6438552) SNPs had no association with development of early-onset schizophrenia; however, our finding suggested statistically significant role of the interaction of NOS1AP, DISC1, DAOA and GSK3B polymorphisms in schizophrenia susceptibility. PMID: 29100974
  2. Novel Hispanic/Latino-specific Single Nucleotide Polymorphism at NOS1AP implicate gene regulatory dysfunction in QT prolongation. PMID: 27988371
  3. If the expression of Capon is decreased, myeloma cells are adhered to fibronectin or bone marrow stromal cells (bone marrow mesenchymal stem cells). In addition, the sensitivity of the cell line to chemotherapeutic agents was reduced after silencing Capon in the myeloma cell line which was adhered to bone marrow mesenchymal stem cells. PMID: 28671047
  4. sex was identified as a moderator of the association between NOS1AP sequence variants and QTc prolongation in two long QT syndrome founder populations PMID: 28720088
  5. Association between NOS1AP and PTSD severity, depression, anxiety, and stress was found. NOS1AP was associated with resilience. PMID: 28465168
  6. gender modulated the interaction between NOS1AP promoter DNA methylation in intracranial aneurysm and brain arteriovenous malformation BAVM patients PMID: 27080431
  7. results hint towards an involvement of NOS-I/NOS1AP interaction in the regulation of dendritic spine plasticity PMID: 26861996
  8. Results from genome-wide DNA methylation, functional network analysis and pyrosequencing, show selective CpG sites (NOS1AP, BID, and GABRB1) differentially methylated in smokers and chronic obstructive pulmonary disease patients compared to nonsmokers. PMID: 28416970
  9. Data indicate that overexpression of nitric oxide synthase 1 adaptor protein short form (CAPON-S) led to the inactivation of the proto-oncogene protein Akt (Akt) signaling pathway. PMID: 27869735
  10. SNPs in the NOS1AP gene influence QTc interval duration but we have not demonstrated a direct association with the risk of sudden cardiac death PMID: 26332198
  11. Results suggest that NOS1AP variants are associated with various forms of depression in schizophrenia and are more prevalent in males. PMID: 26384012
  12. The study suggested that rs3751284 and rs348624 in the NOS1AP gene might be susceptibility loci for sudden unexplained death during daily activities. PMID: 25639344
  13. report of the association of common NOS1AP polymorphisms with sudden unexplained nocturnal death syndrome in the southern Chinese Han population. These findings suggest that the A allele of rs12567209 and haplotype GCTA may serve as a protective modifier. PMID: 24504561
  14. The A allele of rs12567209 in NOS1AP may serve as an independent predictor of all-cause death and SCD in patients with CHF. PMID: 24418727
  15. This study suggested that NOS1 and NOS1AP were associated with schizophrenia. PMID: 24220657
  16. We further localized NOS1AP to cardiomyocyte intercalated discs (IDs) and demonstrate that overexpression of NOS1AP in cardiomyocytes leads to altered cellular electrophysiology. PMID: 24857694
  17. This is the first study reporting that a variant of the NOS1AP gene is associated with PTSD. Our data also suggest that a genetic variant in NOS1AP may increase the susceptibility to severe depression in patients with PTSD and increased risk for suicide. PMID: 23146198
  18. rs10918859 of the NOS1AP gene is associated with CHD in Han Chinese. In addition, here we report a gender effect in the association between rs10918859 of the NOS1AP gene and CHD. PMID: 23171141
  19. In atherosclerosis, NOS1AP variants were associated with QT in CAU, with weaker evidence for selected variants in HIS and CHN. Location of significant SNPs varied across ancestry. PMID: 23347024
  20. Decreased NOS1AP expression in rs10494366 TT and rs10918594 CC homozygotes may underlie shorter repolarization times.Myocardial tissue for gene expression analysis was obtained from extracted cardiac implantable electronic device. PMID: 22019493
  21. Common variations in the NOS1AP gene are associated with a significant increase in the risk of drug-induced long QT syndrome. PMID: 22682551
  22. NOS1AP colocalizes with both SCRIB and VANGL1 along cellular protrusions in metastatic breast cancer cells, but does not colocalize with either SCRIB or VANGL1 at cell junctions in normal breast cells PMID: 22179838
  23. Common variations in or near CASQ2, GPD1L, and NOS1AP are associated with increased risk of sudden cardiac death in patients with coronary artery disease PMID: 21685173
  24. NOS1AP rs203462 polymorphisms did not correlate with an increased risk of QT interval prolongation among kidney recipients. PMID: 21996201
  25. relationship of nitric oxide synthase 1 adaptor protein (NOS1AP) polymorphism with serum creatinine level and occurrence of delayed graft function in kidney transplant recipients PMID: 21959512
  26. Data show that NOS1AP protein levels are altered in BA46 and cerebellum of patients with schizophrenia. PMID: 20605702
  27. The genetic variant rs12143842 in NOS1AP is associated with QT interval duration in a Chinese population with Type 2 diabetes. PMID: 20722683
  28. NOS1AP has a modest effect on ECG t-wave peak to t-wave end interval but is not related to T-wave morphology measures. PMID: 20215044
  29. the NOS1AP variant is associated with incidence of type 2 diabetes in calcium channel blocker users PMID: 19943157
  30. Two non-synonymous NOS1AP variations, V37I and D423N were identified in two families, one with two siblings with Obsessive-Compulsive Disorder and the other with two brothers with autism spectrum disorders. PMID: 20602773
  31. NOS1AP tag SNP genotype may provide an additional clinical dimension, which helps assess risk and choice of therapeutic strategies in LQTS. PMID: 20538168
  32. NOS1AP variants may not play a dominant role in susceptibility to type 2 diabetes, but a minor effect cannot be excluded. PMID: 19937226
  33. The length of QT interval verify the importance of NOS1AP protein and to identify a SNP on chromosome 13 reaching genome-wide significance. PMID: 20031603
  34. Study provided additional evidence for association between genetic variation within NOS1AP and SCD. PMID: 19643915
  35. these findings support the hypothesis that NOS1 redistribution in injured myocardium requires the formation of a complex with the PDZ adaptor protein CAPON. PMID: 19800018
  36. Sequence analysis revealed that one non-synonymous substitution in exon 8 was observed in one subject, in addition to six SNPs in exons and introns. This study showed variations in NOS1AP might be involved in occurrence of SIDS PMID: 19289301
  37. Our findings indicate that CAPON gene may be a candidate susceptibility gene for schizophrenia in Chinese Han population, and also provide further support for the importance of NMDAR-mediated glutamatergic transmission in the etiology of schizophrenia. PMID: 15707951
  38. study adds support to a role of CAPON in schizophrenia, produces new evidence implicating this gene in the etiology of bipolar disorder, and suggests a possible mechanism of action of CAPON in psychiatric illness PMID: 16146415
  39. The present finding weakens the evidence that mutations or variation in the CAPON gene are causing genetic susceptibility to schizophrenia in European populations. PMID: 16202394
  40. This genome-wide study identified NOS1AP (CAPON), a regulator of neuronal nitric oxide synthase, as a new target that modulates cardiac repolarization PMID: 16648850
  41. NOS1AP variants influence QT interval PMID: 17565224
  42. Strong effects of NOS1AP variants in diabetic individuals suggest that this patient subset may be particularly susceptible to genetic variants that influence myocardial depolarization and repolarization as manifest in the QT interval. PMID: 18235038
  43. provide a rationale for the association of CAPON gene variants with extremes of the QT interval in human populations PMID: 18337493
  44. Our results identified no single marker nor haplotype associated with schizophrenia, which did not suggest that CAPON was a susceptible site in the Chinese Han population. PMID: 18430503
  45. Linkage and association studies from multiple samples drawn from different populations indicate that a schizophrenia susceptibility gene is located in the region of chromosome 1 containing NOS1AP. PMID: 18474209
  46. Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea. PMID: 18551039
  47. Single nucleotide polymorphisms are associated with incidence of diabetes mellitus in people who use calcium channel blockers. PMID: 18766325
  48. Demonstrated that the common NOS1AP variant rs10494366 was associated with increased QT interval in healthy young adults. PMID: 18785031
  49. A common variant (rs10494366T > G) within NOS1AP gene was associated with QT-interval duration. PMID: 18927126
  50. study found significant association between eight SNPs in the NOS1AP gene region to schizophrenia (patients from a South American population isolate) and its clinical dimensions PMID: 19077434

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Database Links

HGNC: 16859

OMIM: 605551

KEGG: hsa:9722

STRING: 9606.ENSP00000355133

UniGene: Hs.731942

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