NPTN Antibody

Datasheet

Code	CSB-PA016028ESR2HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA016028ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NPTN Polyclonal antibody

Uniprot No.

Q9Y639

Target Names

NPTN

Alternative Names

GP55 antibody; GP65 antibody; Neuroplastin antibody; np55 antibody; np65 antibody; Nptn antibody; NPTN_HUMAN antibody; SDFR1 antibody; SDR-1 antibody; SDR1 antibody; stromal cell derived factor receptor 1 antibody; Stromal cell-derived receptor 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Neuroplastin protein (29-200AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity. Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity. Promotes localization of XKR8 at the cell membrane.

Gene References into Functions

Cryoelectron microscopy structure offers important insight into how the NPTN binds to the PMCA1. PMID: 30190470
Xkr8-BSG/NPTN complex is required for phosphatidylserine scrambling in apoptotic cell membranes. PMID: 27503893
This study showed that Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents. PMID: 24514566
correct synaptic membrane protein localization, neuronal energy supply, expression of LTP and LTD, animal and human behaviour, and pathophysiology and disease--{review} PMID: 25040546
NPTN may be involved in genetic susceptibility to schizophrenia. PMID: 17123723
In human brain np65 is prominently present in cerebellum while np55 is the predominant isoform in mouse and rat cerebellum. PMID: 17196182

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell junction, synapse, postsynaptic density.

Tissue Specificity

Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level).

Database Links

HGNC: 17867

OMIM: 612820

KEGG: hsa:27020

STRING: 9606.ENSP00000290401

UniGene: Hs.744867

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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