NUP93 Antibody

Datasheet

Code	CSB-PA822683LA01HU
Size	US$166
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Image	IHC image of CSB-PA822683LA01HU diluted at 1:400 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NUP93 Polyclonal antibody

Uniprot No.

Q8N1F7

Target Names

NUP93

Alternative Names

NUP93 antibody; KIAA0095Nuclear pore complex protein Nup93 antibody; 93 kDa nucleoporin antibody; Nucleoporin Nup93 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Nuclear pore complex protein Nup93 protein (14-180AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The NUP93 Antibody (Product code: CSB-PA822683LA01HU) is Non-conjugated. For NUP93 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA822683LB01HU	NUP93 Antibody, HRP conjugated	ELISA
FITC	CSB-PA822683LC01HU	NUP93 Antibody, FITC conjugated
Biotin	CSB-PA822683LD01HU	NUP93 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling.

Gene References into Functions

we show that knockdown of Nup188 or its binding partner Nup93 leads to a loss of cilia during embryonic development while leaving NPC function largely intact. Many data, including the localization of endogenous Nup188/93 at cilia bases, support their direct role at cilia. Super-resolution imaging of Nup188 shows two barrel-like structures PMID: 27593162
NUP93 and exportin 5 interact with the signaling protein SMAD4 and that NUP93 mutations abrogated interaction with SMAD4 PMID: 26878725
Caspases target only Nup93 and Nup96 within the core structure of the nuclear pore complex PMID: 16286466

Involvement in disease

Nephrotic syndrome 12 (NPHS12)

Subcellular Location

Nucleus membrane; Peripheral membrane protein. Nucleus, nuclear pore complex. Nucleus envelope.

Protein Families

Nucleoporin interacting component (NIC) family

Database Links

HGNC: 28958

OMIM: 614351

KEGG: hsa:9688

STRING: 9606.ENSP00000310668

UniGene: Hs.276878

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Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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