OXR1 Antibody

1. OXR1 may act as a sensor of cellular oxidative stress to regulate the transcriptional networks required to detoxify reactive oxygen species and modulate cell cycle and apoptosis. PMID: 26616534
2. Oxr1 serves as a potential therapeutic target for ALS and other neurodegenerative disorders characterized by TDP-43 or FUS pathology. PMID: 25792726
3. OXR1 upregulates the expression of antioxidant genes via the p21 signaling pathway to suppress hydrogen peroxide-induced oxidative stress and maintain mtDNA integrity. PMID: 25236744
4. The protein segment encoded by exon 8 plays an important role in the anti-oxidative function of the human OXR1 protein. PMID: 22873401
5. Data show that human and yeast oxidation resistance 1 (OXR1) genes are induced by heat and oxidative stress and that their proteins localize to the mitochondria and function to protect against oxidative damage. PMID: 15060142
6. human OXR1 is capable of reducing the DNA damaging effects of reactive oxygen species when expressed in bacteria, indicating the protein has an activity that can contribute to oxidation resistance. PMID: 17391516

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HGNC: 15822

OMIM: 605609

KEGG: hsa:55074

STRING: 9606.ENSP00000405424

UniGene: Hs.127286