PAPSS1 Antibody

1. These results suggest that PAPSS1 inhibition enhances cisplatin activity in multiple preclinical model systems and that low PAPSS1 expression may serve as a biomarker for platin sensitivity in cancer patients. Developing strategies to target PAPSS1 activity in conjunction with platinum-based chemotherapy may offer an approach to improving treatment outcomes PMID: 28790117
2. we found that ectopic expression of oncogenic KRas and HRas in cells resulted in elevated CIB1 expression. We previously described the Ca(2+)-myristoyl switch function of CIB1, and its ability to facilitate agonist-induced plasma membrane localisation of sphingosine kinase 1 (SK1), a location where SK1 is known to elicit oncogenic signalling. PMID: 27941888
3. leptin signalling links a novel SFK/ERK1/2-mediated pathway and SK1 expression. PMID: 25482303
4. SK1 positivity and high expression were significantly associated with cancer and a shorter 5-year and overall survival. PMID: 24587339
5. study showed expression patterns of SULT1E1 and PAPSS in breast and endometrial tissues; the estrogen sulfation enzymes were comparatively higher in the tumorous tissues than adjacent normal tissues; overexpression of SULT1E1 and PAPSS1 retarded MCF-7 cells growth in vivo and in vitro by arresting cell cycles and inducing apoptosis PMID: 22380844
6. SK1 plays an essential role in regulating in vitro paracrine angiogenesis and lymphangiogenesis. PMID: 20335228
7. characterization and expression of bifunctional isoforms PMID: 11931637
8. review of PAPSS biochemistry, molecular biology and genetics PMID: 12716056
9. x-ray crystallographic analysis of 3'-phosphoadenosine-5'-phosphosulfate synthetase 1 PMID: 14747722
10. The kinetic characteristics of the individual sulfurylase and kinase activities of PAPSS isoform 1, the predominant form in human brain, are described. PMID: 15065880
11. Results describe the crystal structure of human PAPSS1 at 1.8 angstroms resolution. PMID: 15755455
12. ATP-sulfurylase domain of PAPS synthetase influences these elements in adenylylsulfate kinase, which may be a mechanism between both domains the this bifunctional enzyme PMID: 17540769
13. a role for PAPSS1 in the cellular sulfonation pathway requirement at a stage during or shortly after MLV provirus establishment, and subsequent influence on gene expression from the viral long terminal repeat promoter PMID: 19008949
14. PAPSS1 maps to chromosome 4q25 and may havea role in hepatocellular carcinoma PMID: 19337310

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HGNC: 8603

OMIM: 603262

KEGG: hsa:9061

STRING: 9606.ENSP00000265174

UniGene: Hs.368610