PDE6A Antibody

Code CSB-PA2109ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA2109ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA2109ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PDE6A Polyclonal antibody
Uniprot No.
Target Names
PDE6A
Alternative Names
5''-cyclic phosphodiesterase subunit alpha antibody; CGPR A antibody; GMP PDE alpha antibody; GMP-PDE alpha antibody; PDE 6 alpha antibody; PDE 6A antibody; PDE V B1 antibody; PDE V-B1 antibody; PDE6A antibody; PDE6A_HUMAN antibody; PDEA antibody; Phosphodiesterase 6 alpha antibody; Phosphodiesterase 6A alpha subunit antibody; Phosphodiesterase 6A antibody; Phosphodiesterase 6A cGMP specific rod alpha antibody; Retinal Rod Photoreceptor cGMP Phosphodiesterase alpha antibody; Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit antibody; Rod cGMP-specific 3'' antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Rod cGMP-specific 3\\\',5\\\'-cyclic phosphodiesterase subunit alpha protein (656-860AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
This protein participates in processes of transmission and amplification of the visual signal.
Gene References into Functions
  1. this is the first phenotypic description of arRP due to homozygous IVS6+1G>A mutations in PDE6A and these seem here to be associated with severe RP leading to early extinction of rod responses as well as reduced macular function. PMID: 27820873
  2. report two splice acceptor site variations in PDE6A in consanguineous Pakistani families who manifested cardinal symptoms of autosomal recessive retinitis pigmentosa PMID: 26321862
  3. analysis of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6 PMID: 23033484
  4. the p.Val685Met mutation in PDE6A causes retinal degeneration in humans PMID: 21039428
  5. Rod phosphodiesterase-6 PDE6A and PDE6B subunits are enzymatically equivalent. PMID: 20940301
  6. full transcriptional activity of the PDE6A gene requires both Nrl and Crx PMID: 15001570
  7. Homozygous single base pair change; c.889C->T, single base pair insertion; c.2218-2219insT, and single base pair substitution in the splice acceptor site; IVS10-2A->G in each of three families. PMID: 17110911

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Involvement in disease
Retinitis pigmentosa 43 (RP43)
Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein Families
Cyclic nucleotide phosphodiesterase family
Database Links

HGNC: 8785

OMIM: 180071

KEGG: hsa:5145

STRING: 9606.ENSP00000255266

UniGene: Hs.567314

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