PHF21A Antibody

Datasheet

Code	CSB-PA017911LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Mouse liver tissue, Mouse kidney tissue All lanes: PHF21A antibody at 3μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 75, 71 kDa Observed band size: 75 kDa Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA017911LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA017911LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA017911LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PHF21A Polyclonal antibody

Uniprot No.

Q96BD5

Target Names

PHF21A

Alternative Names

BHC80a antibody; BM-006 antibody; BRAF35-HDAC complex protein BHC80 antibody; BRAF35/HDAC2 complex (80 kDa) antibody; KIAA1696 antibody; PF21A_HUMAN antibody; PHD finger protein 21A antibody; PHF21A antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human PHD finger protein 21A protein (312-487AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PHF21A Antibody (Product code: CSB-PA017911LA01HU) is Non-conjugated. For PHF21A Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA017911LB01HU	PHF21A Antibody, HRP conjugated	ELISA
FITC	CSB-PA017911LC01HU	PHF21A Antibody, FITC conjugated
Biotin	CSB-PA017911LD01HU	PHF21A Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.

Gene References into Functions

this case lends further support that haploinsufficiency of PHF21A contributes to the intellectual disability and craniofacial abnormalities in PSS and that there are other genes in the region which likely contribute to the behavioral phenotype in this syndrome. PMID: 28127865
we have uncovered evidence that the ID and CFA phenotypes are both caused by haploinsufficiency of a single gene, PHF21A, at 11p11.2. PMID: 22770980
Presumably serves as a scaffold protein in BHC in neuronal as well as non-neuronal cells. Possible role in spermatogenesis. PMID: 15325272
the recovery of neurosecretion depends on the reciprocal level of BHC80 and REST, with BHC80 working as a negative modulator of REST repression PMID: 19439607

Subcellular Location

Nucleus.

Tissue Specificity

Highly expressed in brain. Expressed at lower level in other tissues, including heart, kidney, liver, lung and skeletal muscle. Abundantly expressed in fetal brain.

Database Links

HGNC: 24156

OMIM: 608325

KEGG: hsa:51317

STRING: 9606.ENSP00000398824

UniGene: Hs.502458

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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