PIGL Antibody

Datasheet

Code	CSB-PA897465LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA897465LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA897465LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PIGL Polyclonal antibody

Uniprot No.

Q9Y2B2

Target Names

PIGL

Alternative Names

N acetylglucosaminylphosphatidylinositol deacetylase antibody; N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase antibody; Phosphatidylinositol glycan anchor biosynthesis class L antibody; Phosphatidylinositol glycan class L antibody; Phosphatidylinositol-glycan biosynthesis class L protein antibody; PIG-L antibody; Pigl antibody; PIGL_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase protein (23-252AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PIGL Antibody (Product code: CSB-PA897465LA01HU) is Non-conjugated. For PIGL Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA897465LB01HU	PIGL Antibody, HRP conjugated	ELISA
FITC	CSB-PA897465LC01HU	PIGL Antibody, FITC conjugated
Biotin	CSB-PA897465LD01HU	PIGL Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

Gene References into Functions

c.336-2A>G variant in PIGL associated with developmental disorder resulted in exon skipping. PMID: 28327575
these findings indicate that patients with a clinical diagnosis of CHIME syndrome and a single identifiable mutation in PIGL warrant further investigation for copynumber changes involving PMID: 28371479
fd hrhr rt eruj jej PMID: 25706356
Whole-exome sequencing on five previously reported CHIME cases identified PIGL (N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase) as required for glycosylphosphatidylinositol anchor formation. PMID: 22444671

Involvement in disease

Coloboma, congenital heart disease, ichthyosiform dermatosis, mental retardation and ear anomalies syndrome (CHIME)

Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein.

Protein Families

PIGL family

Database Links

HGNC: 8966

OMIM: 280000

KEGG: hsa:9487

STRING: 9606.ENSP00000225609

UniGene: Hs.499793

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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