PINX1 Antibody

1. Low PINX1 expression is associated with colorectal cancer cell migration, invasion and metastasis PMID: 30015978
2. PinX1 silencing in CD133+ CSCs significantly decreased TRF1, Mad1, and p53 mRNA levels, while it increased hTERT and c-Myc mRNA levels. PMID: 30138944
3. NF-kappaB p65 potentiated tumor growth via suppressing a novel target LPTS PMID: 29017500
4. Our findings suggested that PinX1 could be a potential tumour suppressor in non-small-cell lung cancer and that loss of PinX1 promoted non-small-cell lung cancer progression. PMID: 28815183
5. Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer. PMID: 28586040
6. The cost-effective expression of PinX1 could constitute a novel molecular predictor/marker for NSCLC management. PMID: 28372542
7. PINX1 Polymorphisms are associated with Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B Virus Infection. PMID: 27221889
8. The stability of PinX1 is maintained in nucleolus in the presence of TERT. PMID: 26194824
9. PinX1 negatively regulated ccRCC metastasis and the expression of MMP-2 and NF-kappaB-p65 PMID: 26033551
10. High PinX1 expression significantly correlated with a worse 5-year overall and disease-specific survival in gliomas. PMID: 26261583
11. Data show a novel molecular mechanism for PINX1 as an attenuator of estrogen receptor activity in breast cancer cell lines, furthering its role as a tumor suppressor gene in breast cancer. PMID: 26187699
12. PinX1 protein expression is decreased in colorectal cancer patients and predicts a poor prognosis. PMID: 26211574
13. PinX1 inhibits cell proliferation, migration and invasion in glioma cells. PMID: 25698538
14. PinX1 expression was an independent negative prognostic factor for breast cancer patients. PMID: 25888829
15. Two novel markers, rs7840785 (PINX1) and rs7844465 (ZHX2), are significantly associated with carotid intima-media thickness. PMID: 25746325
16. These results confirmed the role of PinX1 as a major tumor suppressor gene in breast cancer cell lines. PMID: 24672800
17. Data confirmed that levels of PinX1 and caspase 3, 8 and 9 expression were closely linked to the poor prognosis of colorectal cancer. PMID: 24839934
18. the expression of PinX1 in CSCC patients is likely a predictor of the response to paclitaxel chemotherapy. PMID: 25045845
19. The results suggest that activation of Prp43p by Gno1p/PINX1 within early pre-ribosomal particles is crucial for their subsequent maturation. PMID: 24823796
20. Down-regulation of PinX1 play an important role in the tumorigenesis and development of urothelial carcinoma of the bladder. PMID: 24268029
21. these findings suggested that PinX1 may maintain telomere integrity by regulating TRF1 stability and that hTERT may act as both a positive and a negative regulator of TRF1 homeostasis in a PinX1-dependent manner. PMID: 24415760
22. Overexpression of PinX1 blocked Eca109 cell proliferation and induced cell apoptosis by downregulating telomerase activity. PMID: 23912465
23. Data indicate that HPV16 E6 suppresses the expression of PinX1 via inhibiting p53 transcriptional activity, resulting in the enhancement of telomerase activity. PMID: 24412852
24. Suggest that PinX1 could serve as a novel predictor for response to chemoradiotherapy in esophageal squamous cell carcinoma. PMID: 23341363
25. Data are consistent with the earlier data that showed that PINX1 somatic mutation was rare in hepatocellular carcinomas, medulloblatomas, gastric carcinomas, and colorectal carcinomas. PMID: 22882268
26. Silencing of PinX1 significantly reduced the localization of telomerase to telomere during mid-late S phase, suggesting the involvement of PinX1 in the cell cycle-dependent trafficking of hTERT to telomere. PMID: 22749911
27. PinX1 may play important roles in NPC proliferation, migration and apoptosis and has application potential in tumor-targeted gene therapy PMID: 22316341
28. one function of PinX1 is to stabilize TRF1 during mitosis, perhaps to promote transition into M phase of the cell cycle. PMID: 22331467
29. Polo-like kinase 1 (Plk1) is a novel interacting protein of PinX1 and may negatively regulate the stability of PinX1 by mitotic phosphorylation. PMID: 20573420
30. the telomerase inhibitor PinX1 is recruited to telomeres by TRF1 and provides a critical link between TRF1 and telomerase inhibition to prevent telomere elongation and help maintain telomere homeostasis. PMID: 21119197
31. Suppression of telomerase activity mediated by PinX1 is involved in the Mad1/c-Myc pathway. PMID: 20544396
32. loss of PinX1 is an adverse independent molecular marker for epithelial ovarian carcinoma patients. PMID: 20367640
33. these results suggest that the C-terminal fragment of LPTS/PinX1 (LPTS/PinX1(290-328)) contains a telomerase inhibitory domain that is required for the inhibition of telomere elongation and the induction of cell crisis. PMID: 20620128
34. role in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition PMID: 12107183
35. Over-expression of LPTS-L can induce hepatoma cells into crisis due to the reduction of telomerase activity. PMID: 12439923
36. Data show that liver-related putative tumor suppressor gene (LPTS) mutations occur in hepatocellular carcinoma but are infrequent and of little effect on the telomerase inhibitory function of the protein. PMID: 12508358
37. molecular cloning of the 5'-flanking region and determination of the transcription initiation site and four DNase I hypersensitive sites PMID: 14984932
38. in vitro PinX1 binds directly to the hTERT protein subunit, primarily to the hTR-binding domain, as well as to the hTR subunit PMID: 15381700
39. LOH of PINX1 locus associated with reduced expression of PINX1 in gastric cancer PMID: 15637589
40. PINX1 may play major role in gastric cancer development and regulate it through different pathways and expression is a sign of cancer development. PMID: 18784941
41. Results reveal a novel positive role for PinX1 in telomerase/telomere regulations and suggest that the constitutive expression of PinX1 attributes to telomere maintenance by telomerase and tumorigenicity in cancer cells. PMID: 19117989
42. Results show that hPinX1 regulates the nucleolar accumulation and telomeric association of TRF1. PMID: 19265708
43. PinX1 is recruited to chromosome periphery by Nucleolin and a complex of PinX1 and Nucleolin is essential for faithful chromosome congression. PMID: 19393617
44. The results indicate that PinX1 plays an important role in faithful chromosome segregation in mitosis. PMID: 19553660

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HGNC: 30046

OMIM: 606505

KEGG: hsa:54984

STRING: 9606.ENSP00000318966

UniGene: Hs.490991