PKIB Antibody

Datasheet

Code	CSB-PA883651LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA883651LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA883651LA01HU at dilution of 1:100 Immunofluorescent analysis of MCF-7 cells using CSB-PA883651LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PKIB Polyclonal antibody

Uniprot No.

Q9C010

Target Names

PKIB

Alternative Names

cAMP dependent protein kinase inhibitor 2 antibody; cAMP-dependent protein kinase inhibitor beta antibody; FLJ23817 antibody; IPKB_HUMAN antibody; OTTHUMP00000017115 antibody; OTTHUMP00000017116 antibody; OTTHUMP00000017117 antibody; PKI-beta antibody; PKIB antibody; PRKACN2 antibody; Protein kinase (cAMP dependent, catalytic) inhibitor beta antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human cAMP-dependent protein kinase inhibitor beta protein (1-77AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PKIB Antibody (Product code: CSB-PA883651LA01HU) is Non-conjugated. For PKIB Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA883651LB01HU	PKIB Antibody, HRP conjugated	ELISA
FITC	CSB-PA883651LC01HU	PKIB Antibody, FITC conjugated
Biotin	CSB-PA883651LD01HU	PKIB Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Gene References into Functions

results indicate that PKIB promotes cell proliferation and tumorigenesis by activating the PI3K/Akt pathway in non-small cell lung cancer (NSCLC), implying that this is an important underlying mechanism that affects the progression of NSCLC PMID: 27325557
mutation of the pseudosubstrate domain abolished the inhibitory activity of PKIB on protein kinase A activity, but had no effect on the interaction with GPR39, cell protection and induction of SRE-dependent transcription PMID: 24869658
PKIB overexpression was strongly correlated with pAkt expression and triple-negative breast cancer, suggesting that PKIB overexpression might contribute to the tumor behavior and development of breast cancers. PMID: 23224602
human PKIbeta gene (clone 436F11, GenBank with accession number: AF225513) was over-expressed in normal brain tissues PMID: 12061725
PKIbeta may be a novel full-length gene related to human glioma and may provide a new way to gene therapy of glioma. PMID: 19035091
Functional studies of the rat homolog PMID: 2052616
Functional studies of the mouse homolog PMID: 7684369

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Protein Families

PKI family

Database Links

HGNC: 9018

OMIM: 606914

KEGG: hsa:5570

UniGene: Hs.741340

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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