PKIB Antibody

Code CSB-PA883651LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA883651LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA883651LA01HU at dilution of 1:100

  • Immunofluorescent analysis of MCF-7 cells using CSB-PA883651LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PKIB Polyclonal antibody
Uniprot No.
Target Names
PKIB
Alternative Names
cAMP dependent protein kinase inhibitor 2 antibody; cAMP-dependent protein kinase inhibitor beta antibody; FLJ23817 antibody; IPKB_HUMAN antibody; OTTHUMP00000017115 antibody; OTTHUMP00000017116 antibody; OTTHUMP00000017117 antibody; PKI-beta antibody; PKIB antibody; PRKACN2 antibody; Protein kinase (cAMP dependent, catalytic) inhibitor beta antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human cAMP-dependent protein kinase inhibitor beta protein (1-77AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PKIB Antibody (Product code: CSB-PA883651LA01HU) is Non-conjugated. For PKIB Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA883651LB01HU PKIB Antibody, HRP conjugated ELISA
FITC CSB-PA883651LC01HU PKIB Antibody, FITC conjugated
Biotin CSB-PA883651LD01HU PKIB Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Gene References into Functions
  1. results indicate that PKIB promotes cell proliferation and tumorigenesis by activating the PI3K/Akt pathway in non-small cell lung cancer (NSCLC), implying that this is an important underlying mechanism that affects the progression of NSCLC PMID: 27325557
  2. mutation of the pseudosubstrate domain abolished the inhibitory activity of PKIB on protein kinase A activity, but had no effect on the interaction with GPR39, cell protection and induction of SRE-dependent transcription PMID: 24869658
  3. PKIB overexpression was strongly correlated with pAkt expression and triple-negative breast cancer, suggesting that PKIB overexpression might contribute to the tumor behavior and development of breast cancers. PMID: 23224602
  4. human PKIbeta gene (clone 436F11, GenBank with accession number: AF225513) was over-expressed in normal brain tissues PMID: 12061725
  5. PKIbeta may be a novel full-length gene related to human glioma and may provide a new way to gene therapy of glioma. PMID: 19035091
  6. Functional studies of the rat homolog PMID: 2052616
  7. Functional studies of the mouse homolog PMID: 7684369

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Protein Families
PKI family
Database Links

HGNC: 9018

OMIM: 606914

KEGG: hsa:5570

UniGene: Hs.741340

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