PKIB Antibody

1. results indicate that PKIB promotes cell proliferation and tumorigenesis by activating the PI3K/Akt pathway in non-small cell lung cancer (NSCLC), implying that this is an important underlying mechanism that affects the progression of NSCLC PMID: 27325557
2. mutation of the pseudosubstrate domain abolished the inhibitory activity of PKIB on protein kinase A activity, but had no effect on the interaction with GPR39, cell protection and induction of SRE-dependent transcription PMID: 24869658
3. PKIB overexpression was strongly correlated with pAkt expression and triple-negative breast cancer, suggesting that PKIB overexpression might contribute to the tumor behavior and development of breast cancers. PMID: 23224602
4. human PKIbeta gene (clone 436F11, GenBank with accession number: AF225513) was over-expressed in normal brain tissues PMID: 12061725
5. PKIbeta may be a novel full-length gene related to human glioma and may provide a new way to gene therapy of glioma. PMID: 19035091
6. Functional studies of the rat homolog PMID: 2052616
7. Functional studies of the mouse homolog PMID: 7684369

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HGNC: 9018

OMIM: 606914

KEGG: hsa:5570

UniGene: Hs.741340