PPRC1 Antibody

1. PRC and c-MYC can act in concert through Akt-GSK-3 signaling to reprogram gene expression in response to mitochondrial stress. PMID: 27789709
2. PRC is a negative regulator of endothelial inflammation; it negatively regulates endothelial adhesion of monocytes via inhibition of NF kappaB activity PMID: 23954632
3. A general role for PRC in the adaptive response to cellular dysfunction. PMID: 23364789
4. PRC has a role in the rapid modulation of metabolic functions in response to the status of the cell cycle PMID: 19956726
5. overexpression of the PRC pathway is responsible for mitochondrial proliferation in the context of thyroid oncocytoma PMID: 14550271
6. PGC-1 has a role in regulating gluconeogenic genes along with HNF-4alpha and SREBP-1 PMID: 14722127
7. This review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure. PMID: 16511594
8. Upregulation of PGC-1alpha and PGC-1beta in the colorectal tumor cells can be part of an adaptation mechanism to help overcome the severe consequences of mtDNA mutations on oxidative phosphorylation. PMID: 17341490
9. These results revealed that bile acid inhibits the promoter activity of PGC-1 in an SHP-dependent manner. PMID: 17390079
10. Activation of the SIRT1/PGC-1 pathway, in a metabolic context promotes mitochondrial function and this pathway plays a role in neurodegerative disease. Review. PMID: 17937892
11. The results are consistent with a pathway whereby PRC regulates NRF-2-dependent genes through a multiprotein complex involving HCF-1. PMID: 18343819
12. support a role for PRC in the integration of pathways directing mitochondrial respiratory function and cell growth PMID: 19036724
13. Coordinate regulation of nucleus-encoded mitochondrial transcription factors by NRFs and PGC-1 family coactivators is essential to the control of mitochondrial biogenesis PMID: 15684387

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HGNC: 30025

OMIM: 617462

KEGG: hsa:23082

STRING: 9606.ENSP00000278070

UniGene: Hs.533551