PSMC1 Antibody

Datasheet

Code	CSB-PA018888GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

P62191

Target Names

PSMC1

Alternative Names

26S protease regulatory subunit 4 antibody; 26S proteasome AAA-ATPase subunit RPT2 antibody; MGC24583 antibody; MGC8541 antibody; P26s4 antibody; p56 antibody; protease 26S, subunit 4 antibody; Proteasome (prosome macropain) 26S subunit ATPase 1 antibody; Proteasome 26S ATPase subunit 1 antibody; Proteasome 26S subunit ATPase 1 antibody; PRS4_HUMAN antibody; PSMC 1 antibody; Psmc1 antibody; S4 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human PSMC1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Gene References into Functions

P26s4 Associates with the C-Terminal Region of TOPORS. PMID: 26872363
Our results suggest that there is no association between variations or haplotypes in the PSMC1 gene and Parkinson's disease PMID: 22948515
Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity PMID: 20424172
Hepatocytes dying because of inhibition of proteasome function produce massive quantities of the proinflammatory chemokine IL-8, possibly resulting in neutrophil infiltration, increased inflammation, and liver injury. PMID: 14578856
Psmc1 conditional knock-out mice demonstrate that 26S proteasomal dysfunction is sufficient to trigger neurodegenerative disease. PMID: 18701681

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Subcellular Location

Cytoplasm. Nucleus. Membrane; Lipid-anchor.

Protein Families

AAA ATPase family

Database Links

HGNC: 9547

OMIM: 602706

KEGG: hsa:5700

STRING: 9606.ENSP00000261303

UniGene: Hs.356654

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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