PTPN12 Antibody

1. identified a new phosphorylation-based substrate recognition mechanism of PTPN12 by CDK2, which orchestrated signaling crosstalk between the oncogenic CDK2 and HER2 pathways PMID: 28842430
2. PTPN12 plasmid transfection increased PTPN12 mRNA and protein expressions, suppressed cell proliferation and migration, reduced EGFR level, and enhanced caspase 3 activity compared with control and empty plasmid groups. PMID: 29634414
3. PTPN12, PTPRN and PTPN18 were independent prognostic factors in Hepatocellular Carcinoma. PMID: 29742497
4. Here, solved is a crystal structure of the native PTPN12 catalytic domain with the catalytic cysteine (residue 231) in dual conformation (phosphorylated and unphosphorylated). PMID: 29278368
5. this study, with a relative large population, showed that PTPN12 eQTL SNP may interact with HBV mutation on HCC risk. PMID: 27075395
6. MyoVa-Ca(2+) channel interactions are required for proper long-range axon growth in developing spinal cord in vivo. PMID: 27134172
7. PTP-PEST regulates EphA3 activation both by affecting cytoskeletal remodelling and through its direct action as a PTP controlling EphA3 phosphorylation. PMID: 26644181
8. Study suggests that PTPN12 expression is a valuable prognostic biomarker for non-small cell lung cancer. PMID: 25868976
9. PTPN12 expression decreases in human renal cell carcinoma PMID: 26537073
10. The decrease expression of PTPN12 might be important in conferring a more aggressive behavior in NPC. Thus, PTPN12 expression may be used as a novel independent prognostic biomarker for patients with NPC. PMID: 25663493
11. PTPN12 is potentially a methylation-silenced TSG for breast cancer that may play an important role in breast carcinogenesis and could potentially serve as an independent prognostic factor for invasive breast cancer patients. PMID: 23044628
12. Decreased expression of PTPN12 correlates with tumor recurrence and poor survival of patients with hepatocellular carcinoma. PMID: 24475046
13. these data suggest that PTP-PEST affects epithelial cell motility by controlling the distribution and phosphorylation of p120 and its availability to control Rho GTPase activity. PMID: 24284071
14. The involvement of PTPN12 in the antioxidant response of breast cancer cells suggests that PTPN12 may represent a novel therapeutic target for this disease PMID: 23435421
15. Overexpression of PTPN12 inhibited proliferation and migration in OSCC cells. PMID: 23733313
16. MRNAs of PTPN12, MSH6, and ZEB1 orthologous genes from different animal species have binding sites for hsa-miR-1279 which consist of homologous oligonucleotides encoding similar human oligopeptides PMID: 23957009
17. High expression of PTPN12 is associated with favorable disease free survival in esophageal squamous cell carcinoma patients. PMID: 22429674
18. activated Ras induces extracellular signal-regulated kinase 1 and 2-dependent phosphorylation of PTP-PEST at S571, which recruits PIN1 to bind to PTP-PEST PMID: 21876001
19. Using a genetic screen, study identifies the PTPN12 tyrosine phosphatase as a tumor suppressor in PMID: 21376233
20. PTP-PEST functions as a suppressor of epithelial cell motility by controlling Rho GTPase activity and the assembly of adherens junctions. PMID: 20519451
21. PTP-PEST actively contributes to the cellular apoptotic response and reveal the importance of caspases as regulators of PTPs in apoptosis. PMID: 17130234
22. These data demonstrate that LPXN forms a signaling complex with Pyk2, c-Src, and PTP-PEST to regulate migration of prostate cancer cells. PMID: 17329398
23. No association was detected between individual PTPN12 tag SNPs and GD but preliminary evidence suggests PTPN12 confers an increased risk of mild/moderate ophthalmopathy (NOSPECS classes 2-4) and that PTPN12 interacts with the TSHR. PMID: 17608818

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HGNC: 9645

OMIM: 600079

KEGG: hsa:5782

STRING: 9606.ENSP00000248594

UniGene: Hs.61812