RAB11FIP3 Antibody

Datasheet

Code	CSB-PA441575
Size	US$297
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Image	Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using RAB11FIP3 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RAB11FIP3 Polyclonal antibody

Uniprot No.

O75154

Target Names

RAB11FIP3

Alternative Names

RAB11FIP3 antibody; ARFO1 antibody; KIAA0665 antibody; Rab11 family-interacting protein 3 antibody; FIP3-Rab11 antibody; Rab11-FIP3 antibody; Arfophilin-1 antibody; EF hands-containing Rab-interacting protein antibody; Eferin antibody; MU-MB-17.148 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from C-terminal of Human RAB11FIP3.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:50-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track).

Gene References into Functions

RAB11FIP3 combines with Eps15 homology domain 1 to promote the endocytosis recycling of phosphorylation of epithelial growth factor receptor. PMID: 28215104
Rab11-FIP3 coordinates the interactions of ASAP1 and Rab11a with Rabin8. PMID: 25673879
CART1 might be a cytoplasmic, testis-specific derepressor of RAR PMID: 20736163
FIP3 was identified as the first membrane-associated interacting-partner for DLIC-2. PMID: 20214888
Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis PMID: 15158446
Necessary for the structural integrity of the pericentrosomal endosomal recycling compartment. PMID: 17394487
FIP3 is a scaffolding protein that, in addition to regulating endosome targeting to the cleavage furrow, also is required for Arf6 recruitment to the midbody during late telophase. PMID: 17628206
Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton.(325-41) PMID: 19327867

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Subcellular Location

Recycling endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody.

Database Links

HGNC: 17224

OMIM: 608738

KEGG: hsa:9727

STRING: 9606.ENSP00000262305

UniGene: Hs.531642

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Endocytosis

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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