RBM17 Antibody

Datasheet

Code	CSB-PA853432ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA853432ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA853432ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RBM17 Polyclonal antibody

Uniprot No.

Q96I25

Target Names

RBM17

Alternative Names

45 kDa-splicing factor antibody; RBM 17 antibody; Rbm17 antibody; RNA binding motif protein 17 antibody; RNA-binding motif protein 17 antibody; SPF 45 antibody; SPF45 antibody; SPF45_HUMAN antibody; Splicing factor (45 kD) antibody; Splicing factor (45kD) antibody; Splicing factor 45 antibody; Splicing factor 45 kDa antibody; Splicing factor 45kDa antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Splicing factor 45 protein (1-240AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.

Gene References into Functions

this work provides the structural and molecular basis of the interaction between RBM17 and the phosphorylated form of ATXN1. PMID: 24858692
identify SPF45 as the first splicing factor regulated by multiple MAP kinase pathways and show effects of both SPF45 overexpression and phosphorylation PMID: 22615491
dephosphorylation of pS776-ATXN1 by PP2A regulates the interaction of ATXN1 with the splicing factors RBM17 and U2AF65 PMID: 21835928
overexpression of SPF45 in HeLa, a cervical carcinoma cell line, resulted in drug resistance to doxorubicin and vincristine PMID: 14578179
The SPF45 regulates alternative splicing of the apoptosis regulatory gene CD95; 2.1-A crystal structure of SPF45-UHM in complex with a ULM peptide from SF3b155 is reported. PMID: 17589525
Resistance to various chemotherapeutics resulting from stable transfection of RBM17 (SPF45) in A2780 ovarian carcinoma cells may be due to effects of SPF45 on transcription and splicing of ERbeta-regulated genes. PMID: 16061639

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Subcellular Location

Nucleus.

Database Links

HGNC: 16944

OMIM: 606935

KEGG: hsa:84991

STRING: 9606.ENSP00000369218

UniGene: Hs.498548

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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