RNF19A Antibody

1. A more than 2-fold higher level of RNF19A mRNA in the blood of patients with prostate cancer than in healthy controls makes it an early diagnosis marker for this disease. PMID: 22493721
2. Dorfin has a role in ubiquitylating mutant SOD1 proteins and targeting them for proteasomal degradation PMID: 12145308
3. results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 PMID: 12750386
4. These results suggest that Dorfin plays a crucial role in the formation of ubiquitylated inclusions of alpha-synucleinopathy and amyotrophic lateral sclerosis. PMID: 12875980
5. Reducing the accumulation of mutant superoxide dismutase 1 [SOD1] in the mitochondria may be a new therapeutic strategy for mutant SOD1-associated familial amyotrophic lateral sclerosis, and Dorfin may play a significant role in this PMID: 15030390
6. Valosin-containing protein functionally regulates Dorfin through direct interaction PMID: 15456787
7. Findings suggest that RNF19 has acquired a new promoter and alternative exons via continuous retrotransposition. PMID: 18721867

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HGNC: 13432

OMIM: 607119

KEGG: hsa:25897

STRING: 9606.ENSP00000342667

UniGene: Hs.292882