RPL13A Antibody

Datasheet

Code	CSB-PA05289A0Rb
Size	US$166
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Image	Immunofluorescent analysis of A549 cells using CSB-PA05289A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RPL13A Polyclonal antibody

Uniprot No.

P40429

Target Names

RPL13A

Alternative Names

RPL13A antibody; 60S ribosomal protein L13a antibody; 23 kDa highly basic protein antibody; Large ribosomal subunit protein uL13 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human 60S ribosomal protein L13a protein (63-190AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RPL13A Antibody (Product code: CSB-PA05289A0Rb) is Non-conjugated. For RPL13A Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA05289B0Rb	RPL13A Antibody, HRP conjugated	ELISA
FITC	CSB-PA05289C0Rb	RPL13A Antibody, FITC conjugated
Biotin	CSB-PA05289D0Rb	RPL13A Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.

Gene References into Functions

The expression of RPL13A and EEF1A1 was not affected by differentiation, thus being these genes the most stable candidates as reference genes for RT-PCR. PMID: 27304673
This work identified the arginine residue at position 68 of L13A as being essential for L13A binding to rRNA and incorporation into ribosomes. PMID: 23689135
Ribosomal protein l13a is a reference gene for human bone marrow-derived mesenchymal stromal cells during expansion, adipo-, chondro-, and osteogenesis PMID: 22533734
GAPDH functions as a chaperone, shielding newly released RPL13a from proteasomal degradation. PMID: 22771119
The study found two ribosomal proteins, RPS7 and RPL13A that interact with the HMG (high-mobility group) box domain of SRY. PMID: 21114473
Data show that EF1alpha, RPL13a and YWHAZ are suitable genes for the RT-qPCR analysis and comparison of several sources of human MSC during in vitro characterization and differentiation as well as in an ex vivo animal model of global cerebral ischemia. PMID: 20716364
A translational silencing mechanism involving regulated release of RPL13a and subsequent binding to its target mRNA was elucidated. PMID: 14567916
L13a may have evolved from an essential ribosomal protein in lower eukaryotes to having a role as a dispensable extra-ribosomal function in higher eukaryotes. PMID: 17921318

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Subcellular Location

Cytoplasm.

Protein Families

Universal ribosomal protein uL13 family

Database Links

HGNC: 10304

KEGG: hsa:23521

STRING: 9606.ENSP00000375730

UniGene: Hs.523185

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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