RPL3 Antibody

Code CSB-PA02385A0Rb
Size US$166
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  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA02385A0Rb at dilution of 1:100
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RPL3 Polyclonal antibody
Uniprot No.
Target Names
RPL3
Alternative Names
60S ribosomal protein L3 antibody; HIV-1 TAR RNA-binding protein B antibody; HIV1 TAR RNA binding protein B antibody; MGC103388 antibody; MGC104284 antibody; MGC72934 antibody; Ribosomal protein L3 antibody; Ribosomal protein L3, isoform a antibody; RL3_HUMAN antibody; rpl3 antibody; TARBP B antibody; TARBP-B antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human 60S ribosomal protein L3 protein (2-247AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RPL3 Antibody (Product code: CSB-PA02385A0Rb) is Non-conjugated. For RPL3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA02385B0Rb RPL3 Antibody, HRP conjugated ELISA
FITC CSB-PA02385C0Rb RPL3 Antibody, FITC conjugated
Biotin CSB-PA02385D0Rb RPL3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
Gene References into Functions
  1. The sensitivity of p53 null colon cancer cells to 5-FU can be enhanced using proapoptotic rpL3 gene. PMID: 27835895
  2. nucleolar stress induced by 5-fluorouracil in colon cancer cells devoid of p53 leads to the activation of ribosomal protein L3 as proapoptotic factor PMID: 27385096
  3. We found that uL3 down-regulation correlates positively with multidrug resistance. Restoration of the uL3 protein level re-sensitized the resistant cells to the drug by regulating the reactive oxygen species (ROS) levels, glutathione content, glutamate release, and cystine uptake. PMID: 28273808
  4. rpL3 participates in the cell response to chemotherapy acting as a critical regulator of cell cycle, apoptosis and DNA repair, by modulating p21 expression PMID: 25473889
  5. The rpL3 is able to modulate the protein amounts of p21 through a novel pathway independent from p53 involving Sp1 and NPM. PMID: 23255119
  6. NPM and KHSRP are two newly identified proteins involved in the regulation of rpL3 gene expression via alternative pre-mRNA splicing. PMID: 21705779
  7. working model in which rpL3 recruits hnRNP H1 and, through cooperation with other splicing factors, promotes selection of the alternative splice site PMID: 20100605

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Subcellular Location
Nucleus, nucleolus. Cytoplasm.
Protein Families
Universal ribosomal protein uL3 family
Database Links

HGNC: 10332

OMIM: 604163

KEGG: hsa:6122

STRING: 9606.ENSP00000346001

UniGene: Hs.119598

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