RRAD Antibody

1. our study revealed that RRAD expression was decreased in Hepatocellular carcinoma (HCC) tumor tissues and predicted poor clinical outcome for HCC patients and played an important role in regulating aerobic glycolysis and cell invasion and metastasis and may represent potential targets for improving the treatment of HCC PMID: 26546438
2. Brg1 inhibits proliferation and migration of human aortic smooth muscle cells by directly up-regulating RRAD in aortic dissection. PMID: 26344687
3. RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma. PMID: 25313011
4. RRAD expression is frequently decreased in lung cancer. Ectopic expression of RRAD greatly reduces glycolysis whereas knockdown of RRAD promotes glycolysis in lung cancer cells. PMID: 25114038
5. Rad suppresses the NF-Kappa-B mediated transcription and downstream gene activation. Rad can directly bind to RelA/p65 and suppress the interaction of RelA/p65 with the NF-kappa-B response DNA element. PMID: 24632303
6. Ras(V12)-mediated oncogenic transformation induces RRAD epigenetic inactivation, which in turn promotes glucose uptake and may contribute to ovarian cancer PMID: 24648519
7. RRAD hypermethylation is associated with esophageal squamous cell carcinoma. PMID: 24222170
8. Mouse Rad Q65P (the murine equivalent of human Rad Q66P) inhibits L-type currents conducted by CaV1.2 or CaV1.3 channels as potently as wild-type Rad (>95% inhibition of both channels). PMID: 23973784
9. Rad over expression could be a molecular target to improve bortezomib sensitivity in human leukemia and lymphoma. PMID: 22658652
10. results indicate that RRAD might act as a functional tumor suppressor and its epigenetic inactivation may play an important role in NPC development PMID: 22487779
11. the implication of oxidative stress in modulating Rad expression, in association with the initiation and progression of amyotrophic lateral sclerosis muscle atrophy PMID: 20079427
12. It is proposed for the first time that Rad may promote carcinogenesis at least in part by inhibiting GCIP-mediated tumor suppression. PMID: 20460530
13. crystallization and preliminary crystallographic analysis of human Rad GTPase PMID: 16511212
14. Crystal structure of the GTPase domain of human Rad in the GDP-bound form at 1.8 A resolution. PMID: 16866878
15. Methylation and gene silencing of the Ras-related GTPase gene is associated with lung and breast cancers PMID: 17195088
16. Evidence from Rad transgenic mice suggests that the Rad-associated signaling pathway may play a role in arrhythmogenesis in diverse cardiac diseases. PMID: 17525370
17. Rad is a novel mediator that inhibits cardiac hypertrophy through the CaMKII pathway PMID: 18056528
18. occurrence of an unusual TG 3' splice site in intron 1 PMID: 17672918

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HGNC: 10446

OMIM: 179503

KEGG: hsa:6236

STRING: 9606.ENSP00000299759

UniGene: Hs.1027