SAMD9 Antibody

1. In humans, both SAMD9 and SAMD9L are poxvirus restriction factors, although the latter requires interferon induction in many cell types. PMID: 29447249
2. findings establish SAMD9/SAMD9L mutations as a new class of germline lesions with variable clinical phenotypes, including familial MDS PMID: 28487541
3. Progressive loss of mutated SAMD9 through the development of monosomy 7 (-7), deletions of 7q (7q-), and secondary somatic loss-of-function (nonsense and frameshift) mutations in SAMD9 rescued the growth-restricting effects of mutant SAMD9 proteins in bone marrow and was associated with increased length of survival. PMID: 28346228
4. SAMD9 mutation is associated with MIRAGE syndrome. PMID: 27182967
5. Replication of the K1L(-)C7L(-) mutant vaccinia virus virus was enabled by multiple siRNAs to SAMD9 or WDR6. PMID: 26242627
6. SAMD9 is down-regulated in non-small cell lung cancer. Knockdown of SAMD9 expression increased the invasion, migration and proliferation in H1299 cells in vitro and overexpression of SAMD9 suppressed proliferation and invasion in A549 cells. PMID: 25450373
7. When SAMD9 is stimulated due to failure of the viral antagonism during infection, the resulting antiviral granules exhibit properties different from those of the canonical stress granules. PMID: 25428864
8. Over-expression of SAMD9 is correlated with the metastasis of esophageal squamous cell carcinoma PMID: 24721411
9. M062 also binds and antagonizes cellular SAMD9 in human cells, suggesting that SAMD9 is a novel innate antiviral factor against poxviruses. PMID: 21248034
10. SAMD9, an IFN-gamma-responsive protein, interacts with RGL2 to diminish the expression of EGR1, a protein of direct relevance to the pathogenesis of ectopic calcification and inflammation. PMID: 21160498
11. SAMD9 could be a key molecule to control cancer cell death by inactivated Sendai virus particle or IFN-beta treatment. PMID: 19830690
12. Mutation analysis revealed a homozygous mutation in the SAMD9 gene (K1495E), which was found to segregate with the disease in all families and to interfere with the protein expression. PMID: 16960814
13. SAMD9 and SAMD9L are a novel family of genes, which play a role regulating cell proliferation and suppressing the neoplastic phenotype; the human gene exists in rat, but is lost in mouse, due to a mouse specific rearrangement PMID: 17407603
14. PIvotal role in calcification and thus implicated in various hereditary diseases such as atherosclerosis, calcinosis and autoimmune diseases. PMID: 17507861
15. SAMD9 may have a role in the TNF-alpha signaling pathway and in the regulation of extra-osseous calcification PMID: 18094730

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HGNC: 1348

OMIM: 610455

KEGG: hsa:54809

STRING: 9606.ENSP00000369292

UniGene: Hs.65641