SERPINB13 Antibody

1. clade B serpins help to maintain homeostasis by inducing protective humoral immunity PMID: 22593614
2. These data demonstrate that RUNX1 is an important regulator of SERPINB13 and cathepsin K activity. PMID: 21723253
3. A novel member of the serine proteinase inhibitor (Serpin) gene family that was originally cloned from a keratinocyte cDNA library. It has specificity for inhibiting lysosomal cysteine proteinases. PMID: 12504904
4. Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis. PMID: 12809493
5. hurpin is expressed in skin and has a possible role in inflammatory processes or the regulation of endogenous or pathogen-derived proteinase activity PMID: 15885077
6. Down-regulation of SERPINB13 is associated with head and neck squamous cell carcinoma PMID: 16357159
7. the expression of hurpin was confined mainly to the basal layer in normal skin samples, whereas hurpin was overexpressed and redistributed in diseased skin PMID: 16433682
8. Downregulation of SERPINB13 protein expression in HNSCC is positively associated with poor clinical outcome. Therefore, SERPINB13 seems to act as an important protease inhibitor involved in the progression of HNSCC. PMID: 19569240

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HGNC: 8944

OMIM: 604445

KEGG: hsa:5275

STRING: 9606.ENSP00000341584

UniGene: Hs.241407