SH3KBP1 Antibody

1. The multiple Src homology 3 (SH3) domains of trimeric CIN85 molecules associated with multiple SLP-65 molecules, which recruited further CIN85 trimers, thereby perpetuating the oligomerization process. PMID: 27353366
2. these data support a role for the novel PP2Ac-CIN85 complex in supporting integrin-dependent platelet function by dampening the phosphatase activity. PMID: 27334924
3. CIN85 promotes recycling of TGF-beta receptors and thereby positively regulates TGF-beta signaling. PMID: 26169354
4. Results support the model that Cbl-CIN85-endophilin complex is not required for efficient internalization of EGFR, a prototype RTK. PMID: 25449262
5. Multiple molecular forms of adaptor protein Ruk/CIN85 specifically associate with different subcellular compartments in human breast adenocarcinoma cell line. PMID: 25816594
6. LOX-PP interacts with CIN85 via a novel SH3-binding motif and this association reduces CIN85-promoted invasion by breast cancer cells. PMID: 24167568
7. Data show that EGFR activation leads to a pronounced src-mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR ubiquitination. PMID: 22833562
8. this study indicates that high levels of Ruk(l)/CIN85 contribute to the conversion of breast adenocarcinoma cells into a more malignant phenotype via modulation of the Src/Akt pathway. PMID: 22791810
9. Data show that CIN85 (c-Cbl interacting protein of 85 kDa) is constitutively associated with c-Cbl, Cbl-b, and B-cell linker in B cells. PMID: 22262777
10. The CIN85 was constitutively associated with Hrs, and this strengthens the hypothesis of a functional role of CIN85 in endosomal EGFR sorting. PMID: 21635887
11. the ubiquitination and degradation of stimulated FcgammaRIIa mediated by c-Cbl are positively regulated by the adaptor protein CIN85 in a PKC-dependent manner and these events contribute to the termination of FcgammaRIIa signaling. PMID: 21372129
12. the N- and C-termini are important for the structure, stability, and function of the third SH3 domain of CIN85 PMID: 21446695
13. ARAP1 associated with CIN85 affects epidermal growth factor receptor endocytic trafficking. PMID: 21275903
14. High CIN85 is associated with the development and progression of head and neck squamous cell carcinoma. PMID: 20927317
15. CIN85 binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4 PMID: 20221403
16. Ruk/CIN85 induces PAI-1 expression via modulation of HIF-1alpha stability PMID: 20216986
17. The ORF3 protein of hepatitis E virus was found to interact with CIN85 and compete with the formation of the growth factor receptor-Cbl-CIN85 complex, resulting in the reduced ubiquitination of CIN85. PMID: 20130058
18. Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors PMID: 11894095
19. The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met PMID: 11894096
20. CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases PMID: 12177062
21. Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. PMID: 12218189
22. Cd2 antigen is linked to CAPZ via this protein and CMS. PMID: 12690097
23. forms complexes with endonucleases in HEK293 cells PMID: 12946264
24. CIN85 association with Dab2 is essential for its recruitment to clathrin coat and appears to be modulated by growth factor stimulation PMID: 14596919
25. Data show that infected cell protein 0 (ICP0) binds CIN85 in a reciprocal manner and that the complexes pulled down by ICP0 also contain Cbl. PMID: 15824310
26. CIN85 might play an important role in HSV-1 infection. PMID: 16223483
27. Taken together, these results indicate a novel role for CIN85 in the regulation of cellular stress response via the MAPK pathways. PMID: 16256071
28. CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery. PMID: 17255943
29. a new role for CIN85 in regulating Syk protein levels in RBL-2H3 cells through the activation of the ubiquitin-proteasome pathway and provide a mechanism for this regulation involving c-Cbl ligase activity. PMID: 17675467
30. These results suggest that endogenous Ruk/CIN85 may be involved in regulation of specific membrane trafficking processes. PMID: 18266907
31. Results suggest that competition between Cbl and ubiquitin binding to CIN85 regulates Cbl function and EGFR endocytosis. PMID: 18680311
32. Epidermal Growth Factor stimulation increases association of Cbl and Ruk/CIN85, which is dependent on tyrosine phosphorylation of the C-terminal region of Proto-Oncogene Proteins Cbl. PMID: 19166927
33. detailed high-resolution solution structural study of CIN85A and CIN85B binding to proline-arginine peptides derived from the cognate ligands Cbl and Cbl-b PMID: 19268472
34. CIN85 (SH3-domain kinase binding protein 1) associates with TNF receptor 1 via Src and modulates TNF-alpha-induced apoptosis. PMID: 15707590

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HGNC: 13867

OMIM: 300374

KEGG: hsa:30011

STRING: 9606.ENSP00000380921

UniGene: Hs.726365