SKI Antibody

1. The correlation between serum concentrations of IgG4 and SKI methylation levels suggest SKI might be involved in the pathogenesis of autoimmune pancreatitis (AIP). PMID: 29534839
2. A microRNA miR-155 regulates transforming growth factor-beta TGF-beta-induced human coronary artery endothelial cells fibrogenic endothelial-mesenchymal transition via the regulator of TGF-beta signaling c-Ski to affect cardiac fibrosis, and miR-155/c-Ski may represent novel biomarkers and therapeutic targets for cardiac fibrosis. PMID: 28607031
3. Study identified Ski as a functional tumor suppressor with frequent epigenetic inactivation in lung cancer. PMID: 28398634
4. Transforming Growth Factor beta inhibitor peptide P144 downregulates SKI and an upregulates SMAD7 at both transcriptional and translational levels in glioblastoma cell lines. PMID: 27473823
5. miR-1908 had a positive role in scar formation by suppressing Ski-mediated inflammation and fibroblast proliferation in vitro and in vivo. PMID: 27256397
6. Overexpression of Ski wild type, but not S326D and S383D mutants inhibited centrosome amplification and cellular transformation induced by AURKA. PMID: 26138431
7. our findings suggest that Ski represses TGF-b-induced EMT and invasion by inhibiting SMAD-dependent signaling in non-small cell lung cancer PMID: 25955797
8. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. PMID: 25670202
9. Eight recurrent and three novel SKI mutations from eleven SGS patients were located in the R-SMAD binding domain, except for one in the DHD domain. PMID: 24736733
10. acetaldehyde up-regulates COL1A2 by modulating the role of Ski and the expression of SMADs 3, 4, and 7. PMID: 24641900
11. c-Ski is an important regulator in the activation of CAFs and may serve as a potential therapeutic target to block breast cancer progression. PMID: 24011664
12. Ski expression is a novel negative feedback mechanism acting on retinoic acid signaling PMID: 23441061
13. Overall, these studies demonstrate altered Ski protein levels, degradation and localization in human papillomavirus16-transformed human keratinocytes and in cervical cancer. PMID: 23809940
14. The 1p36.33-1p36.32 deletion encompassing SKI may represents a previous undescribed microdeletion disorder. PMID: 23892090
15. Transgenic K562 cells have distinct gene expression profiles both in steady state and during terminal erythroid differentiation, with GATA1s expression characterised by lack of repression of MYB, CCND2 and SKI. PMID: 22853316
16. The study data provide limited support for the hypothesis that common SKI variants are susceptibility factors for non-syndromic cleft lip/palate. PMID: 22984993
17. We identified causative variation in ten individuals with SGS in the proto-oncogene SKI, a known repressor of TGF-beta activity. PMID: 23023332
18. our findings show that in-frame mutations in exon 1 of SKI cause Shprintzen-Goldberg syndrome (SGS). PMID: 23103230
19. Two genes were consistently retained in the models with clinical variables: SKI (v-SKI avian sarcoma viral oncogene homolog) and SLAMF1 (signaling lymphocytic activation molecule family member 1; CD150). PMID: 22194822
20. A mutant SKI defective in transformation fails to increase p53 ubiquitination and is unable to increase MDM2 levels and to increase mono-sumoylation of Ubc9 PMID: 22411991
21. Ski expression in breast neoplasms is associated with longer overall and disease-free survival. PMID: 22229264
22. Forced expression of miR-29a down-regulated SKI and its target gene, Nr-CAM, whereas miR-29a inhibition induced SKI expression. PMID: 21685371
23. These results suggest that c-Ski is likely involved in the carcinogenesis of CCA induced by O. viverrini infection PMID: 20853076
24. impairment of SKI expression is not the leading mechanism involved in the growth-suppressive effect of miR-155 found in this malignancy. PMID: 21466664
25. These data identify Ski as a novel target of Aurora A and contribute to an understanding of the role of these proteins in the mitotic process. PMID: 21600873
26. Ski correlated with poor survival in the patients with TGF-beta-positive advanced gastric cancer. PMID: 21107877
27. Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1. PMID: 21149449
28. Results identified serine 515 as a phosphorylation site of c-Ski which affects its electrophoretic motility. PMID: 20624875
29. c-Ski overexpression is associated with tumor progression. PMID: 20959473
30. the results suggest that association with Ski leads to inhibition of Siah2 E3 ubiquitin ligase activity and in this way, the Ski protein inhibits Siah2-mediated proteasomal degradation of HDAC3. PMID: 20691163
31. SKI promotes the switch of Smad3 from repressor of proliferation to activator of oncogenesis by facilitating phosphorylations in the linker domain. PMID: 20404506
32. findings show that Arkadia regulates the levels of expression of c-Ski protein in cell-type-dependent fashion, and exhibits a tumour suppressor function by inhibiting tumour cell growth PMID: 19959502
33. Results indicate that SKI exploits multiple regulatory levels of the TGF-beta pathway and its deficiency restores TGF-beta tumor suppressor and apoptotic activities in spite of the likely presence of oncogenic mutations in melanoma tumors. PMID: 19845874
34. c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity PMID: 12034730
35. determined the crystal structure of a complex between a conserved Smad4 binding fragment of Ski and the MH2 domain of Smad4 at 2.85 A resolution PMID: 12419246
36. the ability of Ski and SnoN to repress the growth inhibitory function of the Smad proteins is required for their transforming activity. PMID: 12764135
37. I discuss the basis for repression of intracellular TGF-beta signaling by SKI, some additional activities of this protein, and propose that by disrupting multiple tumor suppressor pathways, SKI functions as a melanoma oncogene. PMID: 12793438
38. c-ski and HIPK2 play an important role in the negative regulation of BMP-induced transcriptional activation PMID: 12874272
39. SKI regulates crucial events required for melanoma growth, survival, and invasion. PMID: 14583455
40. c-Ski protein has a role as a transcriptional co-repressor in TGF-beta signaling in esophageal squamous cell carcinoma PMID: 14712482
41. These results suggest that stabilization of inactive Smad complexes on DNA is a critical event in c-Ski-mediated inhibition of TGF-beta signaling. PMID: 15107821
42. Our data suggest that regulated proteolysis of Ski is one of the key mechanisms that control the threshold levels of this proto-oncoprotein, and thus prevents epithelial cells from becoming TGF-beta resistant. PMID: 15122324
43. ski is repressed by Smad7 PMID: 15128733
44. Functional Ski overexpression inhibits TGF-beta-mediated proliferation and prevents growth-arrested Schwann cells from reentering the cell cycle. PMID: 15312649
45. Ski cooperates in the process of transformation in erythroid cells by interfering with GATA1 function PMID: 15542823
46. Ski's increased level and specific relocalization during mitosis PMID: 15806149
47. a novel polymorphism of the SKI gene was found to be associated with a decreased risk for orofacial defects PMID: 16054854
48. subcellular localization of c-Ski may be regulated by proteasome-sensitive processes through amino acid residues 94-210 and 491-548 PMID: 17054724
49. These results indicate that impaired competition with p300 is the possible cause of dysfunction of c-Ski/SnoN in scleroderma fibroblasts and that this might contribute to maintenance of the autocrine TGFbeta loop in this disease. PMID: 17469184
50. Inhibition of Ski through RNA interference restored TGF-beta signaling and growth inhibition in vitro, and decreased tumor growth in vivo. PMID: 17592292

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HGNC: 10896

OMIM: 164780

KEGG: hsa:6497

STRING: 9606.ENSP00000367797

UniGene: Hs.656507