SLC26A8 Antibody

Datasheet

Code	CSB-PA853496LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA853496LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA853496LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA853496LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC26A8 Polyclonal antibody

Uniprot No.

Q96RN1

Target Names

SLC26A8

Alternative Names

SLC26A8 antibody; TAT1 antibody; Testis anion transporter 1 antibody; Anion exchange transporter antibody; Solute carrier family 26 member 8 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Testis anion transporter 1 protein (414-595AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SLC26A8 Antibody (Product code: CSB-PA853496LA01HU) is Non-conjugated. For SLC26A8 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA853496LB01HU	SLC26A8 Antibody, HRP conjugated	ELISA
FITC	CSB-PA853496LC01HU	SLC26A8 Antibody, FITC conjugated
Biotin	CSB-PA853496LD01HU	SLC26A8 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a molecular complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.

Gene References into Functions

Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia. PMID: 23582645
SLC26A8 mutations are not a common cause of male infertility. PMID: 15579655
structural defects in sperm are not caused by abnormal transcription or point mutations of the TAT1 and SEPT4 genes; however, although both proteins are expressed, they are not properly localized at sperm annulus PMID: 19221096

Involvement in disease

Spermatogenic failure 3 (SPGF3)

Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

SLC26A/SulP transporter (TC 2.A.53) family

Tissue Specificity

Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in s

Database Links

HGNC: 14468

OMIM: 606766

KEGG: hsa:116369

STRING: 9606.ENSP00000347778

UniGene: Hs.435836

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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