SLC30A2 Antibody

1. ZNT2 was localized on the cell surface of both human and mouse beta-cells, suggesting a role of ZNT2 in direct export of zinc out of the beta-cell PMID: 29372370
2. Article highlights the importance of early diagnosis of SLC30A2/ZnT2 variants in order to supplement zinc-deficient infants in real-time, thus preventing TNZD morbidity and enhancing newborn health. [Review] PMID: 28665435
3. many SLC30A2/ZnT2 mutations cause or potentially cause transient neonatal zinc deficiency, as shown in three cases of Japanese infants PMID: 27304099
4. findings establish that some heterozygous loss of function ZnT2 mutations disrupt zinc binding and zinc permeation, thereby suggesting a haploinsufficiency state for the unaffected WT ZnT2 allele in Transient Neonatal Zinc Deficiency PMID: 27137936
5. Our study indicates that SLC30A2 variants are common in this population, dysregulate Zn management and can lead to breast cell dysfunction. PMID: 26293594
6. Human ZnT2 expression is regulated by MTF-1. PMID: 25618524
7. PRL-R attenuation post-transcriptionally increased ZnT2 abundance and redistributed intracellular Zn pools into lysosomes and mitochondria. PMID: 24333596
8. Results indicated that -697G>T and 1031A>G polymorphisms in the SLC30A2 gene may be associated with low-milk-zinc in Chinese breastfeeding women. PMID: 22364884
9. inactivating ZnT-2 mutations are an underlying basis of TNZD and provide the first evidence for the dominant inheritance of heterozygous ZnT-2 mutations via negative dominance due to homodimer formation. PMID: 22733820
10. Pancreatic release of zinc by acinar cells is through the secretory process and apical membrane and involves transporter ZnT2 PMID: 21462106
11. a mutation in SLC30A2 (ZnT-2) may have a role in transient neonatal zinc deficiency PMID: 17065149
12. ZnT2 can facilitate vesicular zinc accumulation independently of AP-3 function, and validate the M1 fibroblastoid line as a human cell culture system amenable to the study of vesicular zinc regulation. PMID: 17349999
13. hZnT-2 was not detectable in leukocytes. PMID: 17971500
14. The localization and function of each ZnT2 isoform, was examined. PMID: 19496757

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HGNC: 11013

OMIM: 608118

KEGG: hsa:7780

UniGene: Hs.143545