SLC4A2 Antibody

1. The regulation of a basolateral located, DIDS-sensitive, Cl(-)/HCO3(-) exchanger, anion exchanger 2 (AE2; SLC4A2) which is postulated to act as an acid loader, and therefore potential regulator of HCO3(-) secretion, in human airway epithelial cells. PMID: 28455748
2. To match the stimulatory effect on acid uptake, cell-to-cell coupling in NHDF-Ad and CCD-112-CoN cells was strengthened with TGFbeta1.Importantly, the activities of stromal AE2 and connexin-43 do not place an energetic burden on cancer cells, allowing resources to be diverted for other activities PMID: 27543333
3. ABA transport in human nucleated cells occurs via the anion exchanger AE2 PMID: 27015766
4. down-regulation in primary biliary cholangitis sensitizes cholangiocytes to apoptotic insults by activating soluble adenylyl cyclase PMID: 26991014
5. regulatory proteins for Cl(-)/HCO3(-) exchanger 2 activity PMID: 26716707
6. AE2 is a major pathway for basolateral Cl(-) loading during cAMP-stimulated secretion of Cl(-) and fluid by Calu-3 cells PMID: 22802585
7. A novel signal pathway involved in gastrin-stimulated AE2 expression mediated by EGR1 in gastric cancer cells. PMID: 23121767
8. miR-506 is up-regulated in primary biliary cirrhosis, binds the 3'UTR region of AE2 mRNA, and prevents protein translation, leading to diminished AE2 activity and impaired biliary secretory functions. PMID: 22383162
9. CTLA4 and SLC4A2 genetic polymorphisms are differentially associated with primary biliary cirrhosis development and progression, as well as anti-gp210 or anti-centromere antibody production, in Japanese PBC patients PMID: 21594562
10. Dysfunctions related to AE2 might have a role in the pathogenesis of primary biliary cirrhosis. PMID: 21691115
11. AE2 mediated-apoptosis of endothelial cells induced by high glucose was Caspase-3-dependent. PMID: 20180022
12. AE2 operates in parallel with NHE1 to regulate pH(i) during RVD of human cervical cancer cells. PMID: 11852051
13. Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells. PMID: 12225956
14. findings suggest that HNF1 may have a major role in upregulating alternative transcription of the AE2 gene in the liver, and therefore it may contribute to the biliary secretion of bicarbonate in response to certain stimuli PMID: 14575719
15. The results indicated that overexpression of AE2 may be involved in the development of human HCC. PMID: 17058451
16. SLC4A2 colocalized with carbonic anhydrase IX in gastric mucosa. PMID: 17652430
17. AE2 might be associated with gastric carcinogenesis and the achlorhydria experienced by gastric cancer patients. PMID: 18438347
18. that AE2 may play an important role in the progression of hepatocellular carcinoma cells PMID: 19224338
19. The common genetic variation of SLC4A2 does not directly affect the risk of PBC or its clinical outcome. PMID: 19491853

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HGNC: 11028

OMIM: 109280

KEGG: hsa:6522

STRING: 9606.ENSP00000405600

UniGene: Hs.647069