SNAP91 Antibody

Code CSB-PA021876DSR1HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SNAP91 Polyclonal antibody
Uniprot No.
Target Names
SNAP91
Alternative Names
SNAP91 antibody; KIAA0656Clathrin coat assembly protein AP180 antibody; 91 kDa synaptosomal-associated protein antibody; Clathrin coat-associated protein AP180 antibody; Phosphoprotein F1-20 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Clathrin coat assembly protein AP180 protein (628-907AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats.
Gene References into Functions
  1. intrinsically disordered domains are highly potent drivers of membrane curvature PMID: 26204806
  2. To sustain efficient neurotransmission and synaptic vesicle formation, AP180 and VAMP2 are required. PMID: 26412491
  3. unique mechanism of SNARE motif-dependent endocytic sorting and identify the ANTH domain proteins AP180 and CALM as cargo-specific adaptors for synaptobrevin endocytosis PMID: 21808019
  4. AP180 is significantly decreased in the hippocampus of Alzheimer's disease patients and in hippocampal neurons of transgenic mice. PMID: 20847448
  5. AP180 had an overall expression similar to synaptophysin, the immunoreactivity for the two proteins did not always co-localize. PMID: 12493563

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Subcellular Location
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
Protein Families
PICALM/SNAP91 family
Database Links

HGNC: 14986

OMIM: 607923

KEGG: hsa:9892

STRING: 9606.ENSP00000358708

UniGene: Hs.368046

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