SNX14 Antibody

Datasheet

Code	CSB-PA806844LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA806844LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA806844LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA806844LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SNX14 Polyclonal antibody

Uniprot No.

Q9Y5W7

Target Names

SNX14

Alternative Names

MGC13217 antibody; RGS-PX2 antibody; RP11-321N4.2 antibody; Snx14 antibody; SNX14_HUMAN antibody; Sorting nexin 14 antibody; Sorting nexin-14 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Sorting nexin-14 protein (601-893AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SNX14 Antibody (Product code: CSB-PA806844LA01HU) is Non-conjugated. For SNX14 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA806844LB01HU	SNX14 Antibody, HRP conjugated	ELISA
FITC	CSB-PA806844LC01HU	SNX14 Antibody, FITC conjugated
Biotin	CSB-PA806844LD01HU	SNX14 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking. Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)).

Gene References into Functions

Here we report on a child with a novel missense mutation in the SNX14 gene that appears to be debilitating for protein conformation, function and review the previously reported cases from 15 families PMID: 27913285
A unique ataxia syndrome due to biallelic SNX14 mutations leading to lysosome-autophagosome dysfunction. PMID: 25848753
SNX19 and SNX14 PX domains reveal key differences in spatial control of RGS-PX proteins in cell signaling and trafficking. PMID: 25148684
Mutations in SNX14 cause a distinctive autosomal-recessive cerebellar ataxia and intellectual disability syndrome. PMID: 25439728

Involvement in disease

Spinocerebellar ataxia, autosomal recessive, 20 (SCAR20)

Subcellular Location

Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell projection, dendrite.

Protein Families

Sorting nexin family

Tissue Specificity

Widely expressed both in fetal and adult tissues.

Database Links

HGNC: 14977

OMIM: 616105

KEGG: hsa:57231

STRING: 9606.ENSP00000313121

UniGene: Hs.485871

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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