SPRED2 Antibody

1. Our findings show that miR-487a, mediated by heat shock factor 1, promotes proliferation and metastasis of Hepatocellular carcinoma (HCC) by PIK3R1 and SPRED2 binding, respectively. Our study provides a rationale for developing miR-487a as a potential prognostic marker or a potential therapeutic target against HCC. PMID: 27827315
2. data indicate that Spred2 induces tumor cell death in an autophagy-dependent manner. PMID: 27028858
3. Spred2 was involved in erythroid differentiation of chronic myeloid leukemia cells and participated in imatinib induced erythroid differentiation partly through ERK signaling. PMID: 25688862
4. Downregulation of SPRED2 mRNA is associated with prostate cancer. PMID: 23169297
5. Data present that galectin-1, ataxin-3 and sprouty-related EVH1 domain-containing protein 2 (SPRED2) may be associated with the progression and development of Down syndrome. PMID: 22777171
6. Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with the p85 subunit of phosphatidylinositol 3-kinase. PMID: 22305891
7. the knockdown of Spred2 markedly enhanced tumor growth in vivo. PMID: 21703232
8. data in the present study suggests that Spred2 is a regulator of TGF-beta1-induced malignance in transformed keratinocytes PMID: 19908229
9. NMR assignment of the human Spred2 EVH1 domain PMID: 15213456
10. Spred-2 was found to be strongly expressed in glandular epithelia and, at the subcellular level, its immunoreactivity was associated with secretory vesicles. It becomes most likely that Spred-2 is involved in the regulation of secretory pathways PMID: 15580519
11. Loss of Spred-2 inhibits bone growth in transgenic mice by inhibiting chondrocyte differentiation through up-regulation of the MAPK signaling pathway. PMID: 15946934
12. These results suggest a role for Spred-2 tyrosine phosphorylation and ubiquitination in controlling Spred-2 expression levels. PMID: 17094949
13. Linkage analysis of SPRED2 excluded its involvement in Cafe-au-lait spots in a patient with a severe form of Noonan syndrome. PMID: 19120036
14. findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1. PMID: 19822672

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HGNC: 17722

OMIM: 609292

KEGG: hsa:200734

STRING: 9606.ENSP00000348753

UniGene: Hs.59332