SRGAP2 Antibody

1. Results show that in high-grade, stage II osteosarcoma samples, expression of SRGAP2 was substantially reduced or absent in over half of the samples. Functional analysis provides further evidence that SRGAP2 may have a role as a suppressor of metastases in osteosarcoma. PMID: 27966608
2. SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration. PMID: 29242313
3. The extended F-BAR (F-BARx) domain of SRGAP2 generates membrane protrusions when expressed in COS-7 cells, while most F-BARs induce the opposite effect: membrane invaginations. As a first step to understand this discrepancy, the F-BARx domain of SRGAP2 was isolated and crystallized after co-expression with the carboxy domains of the protein. Diffraction data were reprocessed with a high-resolution cutoff of 2.2 A. PMID: 27917825
4. human-specific duplication of SRGAP2 might have contributed to the emergence of unique traits of human neurons while preserving the excitation/inhibition balance PMID: 27373832
5. This study illustrated that the role of SRGAP2 protein and its human-specific paralogs in human brain development and evolution. PMID: 23782070
6. interlocus gene conversions in SRGAP2 PMID: 23892896
7. SRGAP2 has been highly conserved over mammalian evolution, and human is the only lineage wherein gene duplications have occurred. Our analysis indicates that the duplications spread across 80 Mbp of chromosome 1 at a time corresponding to the transition from Australopithecus to Homo. PMID: 22559943
8. Results uncover a new function for ancestral SRGAP2 in promoting dendritic spine maturation and indicate that expression of a human-specific paralog of SRGAP2 in mouse pyramidal neurons extends the phase of spine development and leads to an increased density of longer spines in vivo, a feature characterizing pyramidal neurons in the human neocortex PMID: 22559944
9. after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics. PMID: 21148482
10. srGAP2 arginine methylation plays important roles in cell spreading and cell migration through influencing membrane protrusion. PMID: 20810653
11. FNBP2 gene was linked to IKBKE and NORE1 genes on human chromosome 1q32.1. FNBP2 mRNA was expressed in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma. PMID: 12736724

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HGNC: 19751

OMIM: 606524

KEGG: hsa:23380

STRING: 9606.ENSP00000295713

UniGene: Hs.497575