SYNE4 Antibody

Datasheet

Code	CSB-PA847615LA01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SYNE4 Polyclonal antibody

Uniprot No.

Q8N205

Target Names

SYNE4

Alternative Names

SYNE4 antibody; C19orf46 antibody; Nesprin-4 antibody; KASH domain-containing protein 4 antibody; KASH4 antibody; Nuclear envelope spectrin repeat protein 4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Nesprin-4 protein (1-242AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SYNE4 Antibody (Product code: CSB-PA847615LA01HU) is Non-conjugated. For SYNE4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA847615LB01HU	SYNE4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA847615LC01HU	SYNE4 Antibody, FITC conjugated
Biotin	CSB-PA847615LD01HU	SYNE4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus.

Gene References into Functions

progressive high-frequency hearing loss in 2 families of Iraqi Jewish ancestry was due to homozygosity for mutation SYNE4 c.228delAT. SYNE4, a gene not previously associated with hearing loss, encodes nesprin-4, a protein expressed in outer hair cells. PMID: 23348741

Involvement in disease

Deafness, autosomal recessive, 76 (DFNB76)

Subcellular Location

Nucleus outer membrane; Single-pass type IV membrane protein.

Protein Families

Nesprin family

Database Links

HGNC: 26703

OMIM: 615535

KEGG: hsa:163183

STRING: 9606.ENSP00000316130

UniGene: Hs.436743

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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