Selenot Antibody

Code CSB-PA350436LA01MO
Size US$166
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Selenot Polyclonal antibody
Uniprot No.
Target Names
Selenot
Alternative Names
Selenot antibody; Selt antibody; Thioredoxin reductase-like selenoprotein T antibody; SelT antibody; EC 1.8.1.9 antibody
Raised in
Rabbit
Species Reactivity
Mouse
Immunogen
Recombinant Mouse Thioredoxin reductase-like selenoprotein T protein (20-195AA)
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated

The Selenot Antibody (Product code: CSB-PA350436LA01MO) is Non-conjugated. For Selenot Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA350436LB01MO Selenot Antibody, HRP conjugated ELISA
FITC CSB-PA350436LC01MO Selenot Antibody, FITC conjugated
Biotin CSB-PA350436LD01MO Selenot Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Selenoprotein with thioredoxin reductase-like oxidoreductase activity. Protects dopaminergic neurons against oxidative stress ans cell death. Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion. Plays a role in fibroblast anchorage and redox regulation. In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation. In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion.
Gene References into Functions
  1. Selenoprotein T is a novel oligosaccharyltransferase subunit that regulates unfolded protein response signaling and ASTH secretion. PMID: 28928140
  2. SelT exerts a neuroprotective role which is essential during brain development, and that its loss impairs mice behavior. PMID: 26497036
  3. The SelT play a crucial role in the protection of dopaminergic neurons against oxidative stress and cell death, providing insight into the molecular underpinnings of this stress in PD. PMID: 26866473
  4. Data suggest SelT is expressed in pancreatic beta- and delta-cells; inactivation of SelT in beta-cells leads to glucose intolerance via impaired glucose homeostasis and PACAP (pituitary adenylate cyclase-activating polypeptide) insulinotropic effect. PMID: 23913443
  5. Data show that the loss of SelT elevates expression of another selenoprotein, selenoprotein W, suggesting that SepW1 may functionally compensate for SelT. PMID: 19935881

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Subcellular Location
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein Families
SelWTH family, Selenoprotein T subfamily
Tissue Specificity
Ubiquitous. Highly expressed in the endocrine pancreas. Expressed at low levels in the adult brain.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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