Name: TFB2M Antibody
Brand: CUSABIO
SKU: CSB-PA867154LA01HU

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TFB2M Polyclonal antibody

Uniprot No.

Q9H5Q4

Target Names

TFB2M

Alternative Names

N''-adenosyl(rRNA) dimethyltransferase 2 antibody; S adenosylmethionine 6 N', N' adenosyl(rRNA) dimethyltransferase 2 antibody; Dimethyladenosine transferase 2 antibody; dimethyladenosine transferase 2 mitochondrial antibody; FLJ22661 antibody; FLJ23182 antibody; h mtTFB antibody; h mtTFB2 antibody; h-mtTFB antibody; h-mtTFB2 antibody; HCV NS5A transactivated protein 5 antibody; HCV NS5A-transactivated protein 5 antibody; hepatitis C virus NS5A transactivated protein 5 antibody; Hepatitis C virus NS5A-transactivated protein 5 antibody; Hkp1 antibody; hTFB2M antibody; Mitochondrial 12S rRNA dimethylase 2 antibody; mitochondrial antibody; Mitochondrial dimethyladenosine transferase 2 antibody; Mitochondrial transcription factor B2 antibody; mtTFB antibody; mtTFB2 antibody; NS5ATP5 antibody; S-adenosylmethionine-6-N'' antibody; TFB2M antibody; TFB2M_HUMAN antibody; Transcription Factor B2 antibody; Transcription factor B2 mitochondrial antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Dimethyladenosine transferase 2, mitochondrial protein (30-108AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TFB2M Antibody (Product code: CSB-PA867154LA01HU) is Non-conjugated. For TFB2M Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA867154LB01HU	TFB2M Antibody, HRP conjugated	ELISA
FITC	CSB-PA867154LC01HU	TFB2M Antibody, FITC conjugated
Biotin	CSB-PA867154LD01HU	TFB2M Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity.

Gene References into Functions

Study reports crystal structures of human mitochondrial transcription initiation complexes assembled on both light and heavy strand promoters. The structures reveal how transcription factors TFAM and TFB2M assist mitochondrial RNA polymerase to achieve promoter-dependent initiation. PMID: 29149603
demonstrate that a complex composed of TFAM and POLRMT was readily formed at the promoter but alone was insufficient for promoter melting, which only occurred when TFB2M joined the complex PMID: 28028173
The results reveal the organization of TFAM, POLRMT and TFB2M around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex. PMID: 24413562
only two essential initiation factors, TFAM and TFB2M, and two promoters, LSP and HSP1, are required to drive transcription of the mitochondrial genome PMID: 20410300
The mRNA levels of TFB1M and TFB2M are influenced by endurance training PMID: 19681768
This transcription factor activates transcription of human mitochondrial DNA. PMID: 12068295
Distinct, but possibly coordinated functions of mtTFB1 and mtTFB2 in mitochondrial gene expression and biogenesis. PMID: 17557812
This study suggested that DNA variants in TFB2M did not contribute to the risk for parkinson disease. PMID: 18980857
determined the variation in the TFAM, TFB1M, and TFB2M genes in cardiac hypertrophy PMID: 19096125
rRNA methyltransferase activity is necessary for induction of mitochondrial biogenesis by TFB1M, but not TFB2M. PMID: 19417006
Promoter-independent DNA conformation-dependent transcription required TFB2M. PMID: 19624753

Hide All

Subcellular Location

Mitochondrion.

Protein Families

Class I-like SAM-binding methyltransferase superfamily, rRNA adenine N(6)-methyltransferase family, KsgA subfamily

Tissue Specificity

Ubiquitously expressed.

Database Links

HGNC: 18559

OMIM: 607055

KEGG: hsa:64216

STRING: 9606.ENSP00000355471

UniGene: Hs.7395

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Code	CSB-PA867154LA01HU
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TFB2M Antibody

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Target Background