THSD1 Antibody

Datasheet

Code	CSB-PA038075
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA038075(THSD1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details
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Target Background

Product Details

Uniprot No.

Q9NS62

Target Names

THSD1

Alternative Names

4833423O18Rik antibody; MGC74971 antibody; Thrombospondin type 1 domain containing protein 1 antibody; Thrombospondin type I domain 1 antibody; Thrombospondin type-1 domain-containing protein 1 antibody; Thrombospondin, type I, domain containing 1 antibody; THSD1 antibody; THSD1_HUMAN antibody; TMTSP antibody; Transmembrane molecule with thrombospondin module antibody; UNQ3010 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human THSD1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix.

Gene References into Functions

THSD1 forms a multimeric protein complex with FAK/talin/vinculin, wherein THSD1 promotes talin binding to FAK but not to vinculin, a key step in nascent adhesion assembly. PMID: 29069646
THSD1 mutation associated with Intracranial Aneurysm and Subarachnoid Hemorrhage. PMID: 27895300
thrombospondin type I domain 1 is a new regulator of endothelial barrier function during vascular development and protects intraplaque microvessels against haemorrhaging in advanced atherosclerotic lesions PMID: 26822228
The THSD1 gene may play a role in the tumorigenesis of colorectal cancer PMID: 22664866
Thrombospondin has a role in inducing RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly PMID: 15371459
The strong immunolocalization of thrombospondin (TSP) in the outer anulus of the intervertebral disc indicates a role for TSP in the avascular status of the adult human disc. PMID: 17047544
These findings suggest that THSD1 is a good candidate tumor suppressor gene. PMID: 18403638

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Subcellular Location

[Isoform 1]: Endosome membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.; [Isoform 2]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.

Database Links

HGNC: 17754

KEGG: hsa:55901

STRING: 9606.ENSP00000258613

UniGene: Hs.325667

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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