TRIM27 Antibody

1. Results showed that TRIM27 was upregulated in colorectal cancer (CRC) tissues, and significantly associated with tumor invasion, metastasis and prognosis. Following TRIM27 inhibition and overexpression in CRC cells, it was found that TRIM27 promoted cell proliferation, possibly via the inhibition of apoptosis and cell cycle regulation. These results suggested that TRIM27 is an oncogenic protein in the progression of CRC. PMID: 29767249
2. Results demonstrated that TRIM27 restricts the intracellular survival of mycobacteria, suggesting that it is a potential host restriction factor for Mycobacterium tuberculosis by enhancing host immune-inflammatory responses mediated by JNK/p38 pathways as well as cell apoptosis. PMID: 27698396
3. RFP scores were higher both in serous and grade 3 endometrioid carcinoma (p > 0.05), and significantly lower in grade 1 endometrioid carcinoma (p < 0.05). PMID: 28155970
4. Studied the expression of TRIM27 in normal ovarian and fallopian tube epithelial cells and in ovarian serous carcinoma cells; correlated TRIM27 expression with clinical and pathological parameters. PMID: 26568293
5. Study found that compared to healthy individuals, Trim27 was significantly upregulated in patients with Parkinson's disease PMID: 25223908
6. The neoplasm leading cell specific expression of integrin beta1 was posttranscriptionally regulated by the TRIM27/MRTF-B complex in response to the loss of intercellular adhesion. PMID: 24794433
7. Authors observed rapid, ICP0-dependent loss of TRIM27 during HSV-1 infection. PMID: 25320289
8. RFP-knockdown ovarian cancer cells exhibited lower carboplatin resistance than control cells. These findings suggest that RFP could be a predictive marker for chemoresistance in ovarian cancer patients. PMID: 23342271
9. These findings provide a cellular and molecular function for MAGE-L2-TRIM27 in retrograde transport, including an unappreciated role of K63-linked ubiquitination and identification of an activating signal of the WASH regulatory complex. PMID: 23452853
10. Data conclude that TRIM27 negatively regulates NOD2-mediated signaling by degradation of NOD2 and suggest that TRIM27 could be a new target for therapeutic intervention in NOD2-associated diseases. PMID: 22829933
11. TRIM27 expression is a modifier of cancer incidence and progression and is a potential target for intervention. PMID: 22556269
12. These findings provide a unique mechanism for regulating class II PI3Ks, and identify TRIM27 as a previously undescribed negative regulator of CD4 T cells. PMID: 22128329
13. role in inducing apoptosis via its RING finger-B box-coiled-coil motif PMID: 12807881
14. the amino-terminal and carboxyl-terminal regions of Mi-2 beta have distinct transcriptional activities and bind to BRG1 and the RET finger protein, forming a multiprotein supercomplex involved in transcriptional regulation. PMID: 14530259
15. RFP selectively ablates Rb function. PMID: 15837424
16. Mi-2beta and RFP, known to be involved in transcriptional repression in the nucleus, co-localize with MCRS1 in the nucleolus and appear to activate the rRNA transcription. PMID: 16186106
17. RFP negatively regulates signaling involved in the antiviral response and inflammation by targeting the IKKs. PMID: 16393995
18. Our study is the first in the literature to show expression of RET finger protein in patients with breast carcinoma PMID: 19232840

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HGNC: 9975

OMIM: 602165

KEGG: hsa:5987

STRING: 9606.ENSP00000366404

UniGene: Hs.440382