UGT2B4 Antibody

Datasheet

Code	CSB-PA085315
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA085315(UGT2B4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA085315(UGT2B4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P06133

Target Names

UGT2B4

Alternative Names

UGT2B4 antibody; UGT2B11 antibody; UDP-glucuronosyltransferase 2B4 antibody; UDPGT 2B4 antibody; EC 2.4.1.17 antibody; HLUG25 antibody; Hyodeoxycholic acid-specific UDPGT antibody; UDPGTh-1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Fusion protein of Human UGT2B4

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol.

Gene References into Functions

Clopidogrel carboxylic acid is metabolized mainly by UGT2B7 and UGT2B4 in the liver and by UGT2B17 in the small intestinal wall. PMID: 29138287
UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females. PMID: 27282283
These data indicate that knocking down PAPSS increases UGT2B4 transcription and mRNA stability as a compensatory response to the loss of SULT2A1 activity PMID: 25948711
Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo PMID: 22092298
The UGT1A8 and UGT2B4 genotypes associated with decreased predicted enzyme activities, were significantly associated with an increased risk of esophageal squamous cell carcinoma. PMID: 22367021
The variation pattern upstream UGT2B4 is highly unusual and may be the result of balancing selection. PMID: 21660508
Extensive splicing of transcripts of the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation. PMID: 20139797
Farnesoid X receptor (FXR) induces the UGT2B4 enzyme in hepatocytes; this study identifies UGT2B4 as a novel FXR target gene. PMID: 12806625
UGT2B4 expression is regulated by PPARalpha PMID: 12810707
P.1053: "...UGT2B4...is...fairly common in Caucasians...and Africans..."but...still rare in ...Japanese..." P.1054: "...genotyping UGT2B4...in Japanese...would be useful for studies on... association between haplotypes and pharmacokinetic...parameters." PMID: 15319348
Results strongly indicated that the presence of an aromatic residue at position 33 is important for the activity and specificity of UGTB4. PMID: 17263731

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Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein.

Protein Families

UDP-glycosyltransferase family

Database Links

HGNC: 12553

OMIM: 600067

KEGG: hsa:7363

STRING: 9606.ENSP00000305221

UniGene: Hs.285887

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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