WFDC1 Antibody

1. Prostrate stromal 20 overexpression upregulates expression of cyclooxygenase-2 (COX-2) in LNCaP and WPMY-1 cells, and induces expression of a growth-suppressive phenotype, which inhibits proliferation of PCa cells by ps20-expressing WPMY-1 conditioned media. PMID: 27115470
2. HIV-1 virus transfer among primary CD4+ T-lymphocytes was promoted by ectopic ps20 expression or by exogenous addition of recombinant ps20. PMID: 21545747
3. results suggest a minor role, if any, of WFDC1 in hepatocarcinogenesis PMID: 12032731
4. WFDC1/ps20 is down regulated but not frequently mutated in prostate cancer. It is expressed predominantly in the normal prostatic stroma. It might play a role in the maintenance of the normal extra cellular matrix milieu in the prostate. PMID: 15305342
5. ps20 promoted HIV entry via fusion and augmented CD54 integrin expression PMID: 17942534
6. data suggest an important role for WFDC1 in inhibiting proliferation of both tumors and senescent cells. Finally, we suggest that the downregulation of WFDC1 might serve as a biomarker for cellular transformation PMID: 18842679
7. suggests that the tumor suppressive function of WFDC1 may be partially a result of up-regulated Dkk1 gene expression, which is known to be a potent inhibitor of the Wnt signaling pathway PMID: 19488830
8. our data suggest an important role for WFDC1 in inhibiting proliferation of both tumors and senescent cells PMID: 18842679

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HGNC: 15466

OMIM: 605322

KEGG: hsa:58189

STRING: 9606.ENSP00000219454

UniGene: Hs.36688