ZBTB48 Antibody

Datasheet

Code	CSB-PA026340DSR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA026340DSR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ZBTB48 Polyclonal antibody

Uniprot No.

P10074

Target Names

ZBTB48

Alternative Names

0610011D15Rik antibody; AI327031 antibody; GLI Kruppel family member HKR3 antibody; HKR3 antibody; Krueppel related zinc finger protein 3 antibody; Krueppel-related zinc finger protein 3 antibody; OTTMUSP00000031803 antibody; pp9964 antibody; Protein HKR3 antibody; RP23-445E20.3 antibody; ZBT48_HUMAN antibody; ZBTB 48 antibody; Zbtb48 antibody; Zinc finger and BTB domain containing 48 antibody; Zinc finger and BTB domain containing protein 48 antibody; Zinc finger and BTB domain-containing protein 48 antibody; Zinc finger protein 855 antibody; ZNF855 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Telomere zinc finger-associated protein (1-280AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A.

Gene References into Functions

study demonstrate through a combination of RNAseq, ChIPseq and expression proteomics experiments that ZBTB48 acts as a transcriptional activator on a small set of target genes, including mitochondrial fission process 1 (MTFP1). This discovery places ZBTB48 at the interface of telomere length regulation, transcriptional control and mitochondrial metabolism PMID: 28500257
this study describes a specific telomere-associated protein: TZAP (telomeric zinc finger-associated protein). Binding of TZAP to long telomeres represents the switch that triggers telomere trimming, setting the upper limit of telomere length. PMID: 28082411
HKR3 potently activated the transcription of the tumor suppressor gene ARF by acting on the proximal promoter region (bp, -149 approximately +53), which contains Sp1 and FBI-1 binding elements (FREs). PMID: 24382891

Subcellular Location

Nucleus. Chromosome, telomere.

Protein Families

Krueppel C2H2-type zinc-finger protein family

Tissue Specificity

Detected in adrenal gland and neuroblastoma.

Database Links

HGNC: 4930

OMIM: 165270

KEGG: hsa:3104

STRING: 9606.ENSP00000366902

UniGene: Hs.502330

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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