ZNF148 Antibody

1. Our findings suggested that ZBP-89 and Sp1 overexpression induced Bak expression in a genetic manner. Increased Bak level was associated with poor patient survival, whereas high level of Sp1 is a beneficial factor for patient survival. PMID: 29653560
2. The results indicate that the association with chr5p15.33-Region 2 may be explained by rs36115365, a variant influencing TERT expression via ZNF148 in a manner consistent with elevated TERT in carriers of the C allele. PMID: 28447668
3. ZNF148 as a gene involved in a newly described intellectual disability syndrome with a recurrent phenotype and postulate that the ZNF148 is a hitherto unrecognized but crucial transcription factor in the development of the corpus callosum. PMID: 27964749
4. A larger role ZBP-89 plays in gene regulation during inflammation.ZBP-89 regulates of MMP-1 expression.ZBP-89 and NF-kappaB appear to bind cooperatively on both promoters. PMID: 26891870
5. ZBP-89 attenuates HDAC3 by increasing IkappaB degradation, dependent on Pin1 but independent of NF-Kappab PMID: 25623232
6. zinc-binding protein-89 upregulates the expression of Bak by targeting multiple components of the epigenetic pathway in hepatocellular carcinoma. PMID: 23954442
7. lower expression of ZNF148 in colorectal cancer was significantly associated with worse clinicopathologic variables, including lymph node metastases, poor differentiation, and a higher rate of disease recurrence PMID: 23576061
8. this study provides vigorous evidence that ZBP-89 was significantly downregulated in clear cell renal cell carcinoma(CCRCC) and could be served as a promising biomarker for prediction of distal metastasis and prognosis of patient with CCRCC. PMID: 22982674
9. Colony formation was reduced dramatically in those hepatocellular carcinoma cell lines in which ZBP-89 overexpression was demonstrated; this appeared to correlate with increased apoptosis. PMID: 22372401
10. We found that the TP53-G245D variant but not TP53-R249S abrogated HDAC inhibitor p21 induction by binding to ZBP-89 and retaining it in the cytoplasm. PMID: 22214764
11. ZBP-89 is a regulator of Pdcd4 gene, binding to the basal promoter either alone or by interacting with Sp family members. PMID: 22111549
12. An activating role for ZBP-89 in human globin gene regulation and erythroid differentiation. PMID: 21828133
13. Alternative binding of ZBP89 or SP1 to the described region in the IRS2 promoter regulates neuronal IRS2 expression in a PI3K-dependent manner. PMID: 19875459
14. ZBP-89 is a repressor of the human beta 2-integrin CD11b gene during differentiation of monocytes into macrophages PMID: 12393719
15. ZBP-89 co-localized with p53 in the nucleus in about 67% (12 of 18) of all cases positive for the nuclear p53 protein, suggesting that ZBP-89 may play a role in the nuclear accumulation of the p53 protein in a subset recurrent hepatocellular carcinoma. PMID: 12759240
16. interaction of Stat3 and ZBP-89 may be crucial for overcoming the effects of the repressor ZBP-89, which suggests a novel mode for Stat3 gene activation. PMID: 14712222
17. ZBP-89-mediated apoptosis occurs via a p53-independent mechanism that requires JNK activation. PMID: 14963412
18. No association with psoriasis susceptibility PMID: 15175029
19. We conclude that ZBP-89 is a direct transcriptional activator of the enterocyte differentiation marker IAP. PMID: 16384873
20. Ectopic expression of ZBP-89 amplified the inhibitory effect of Fatty Acids on L2 -GH promoter activity. PMID: 16825291
21. ZBP-89 is an important co-activator of wild-type p53 and both proteins are negatively affected by functionally inactive p53 mutants. PMID: 16827139
22. Enhanced ZNF148 expression activates intestinal apoptosis, therefore ZNF148 is a therapeutic target to inhibit colon cancer development. PMID: 17019648
23. ataxia telangiectasia mutated protein phosphorylation of ZBP-89 contributes to Histone deacetylase inhibitors induction of p21(waf1) gene expression PMID: 17560543
24. sumoylation provides a reversible post-translational mechanism to control the activity of ZBP-89. PMID: 17940278
25. Transcription factors Sp3, ZBP-89 and NF-Y are capable of binding to the SOX18 promoter region. PMID: 18496767
26. both NF-kappaB and ZBP-89 bind to the site in vivo and provide evidence of competitive binding to MMP-3 promoter. PMID: 19275880
27. ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in hepatocellular carcinoma cells. PMID: 19362768
28. ZBP-89 iss able to restrain senescence in NCI-H460 human lung cancer cells, through epigenetically regulating p(16INK4a) expression. PMID: 19583777
29. ZBP-89 plays a role in erythroid and megakaryocytic development by cooperating with GATA-1 and/or FOG-1 in a developmental stage-specific manner. PMID: 18250154

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HGNC: 12933

OMIM: 601897

KEGG: hsa:7707

STRING: 9606.ENSP00000353863

UniGene: Hs.592591