notch1a Antibody

1. Results suggest that Notch signaling regulates glycolysis-related gene expression in a context-dependent manner in neural tissues at different developmental stages. PMID: 29913146
2. Notch signalling strength is quantitatively interpreted in different organ systems, and suggest a role for intercellular communication in regulating the output period of the segmentation clock by altering its spatial pattern. PMID: 27302627
3. Results indicate that Jagged-Notch signaling is required for segregation between wt1-expressing cells and differentiated steroidogenic tissue. PMID: 29029162
4. Notch pathway activation and artery formation are integrated during angiogenesis to limit angiogenesis via control of artery formation. PMID: 28714969
5. a highly dynamic endocardium in the regenerating zebrafish heart, with two key endocardial players, Serpine1 and Notch signalling, regulating crucial regenerative processes, is reported. PMID: 28242613
6. Appb-regulated neurogenesis is mediated through balancing the Notch1a signaling pathway and has roles in the development of the Mauthner cell PMID: 26994945
7. Notch1 activation induces expression of ephrin b2a (efnb2a) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch activation in the absence of cardiac contraction rescues efnb2a and nrg1 expression PMID: 26628092
8. Data show that angiopoietin-like proteins zangptl1 and 2 are required for definitive HSPCs formation, and genetically interact with notch receptor. PMID: 25714926
9. Sara and Notch are both essential for cell fate assignation within asymmetric lineages during spinal cord neurogenesis. PMID: 25706234
10. Notch1a and Notch1b, are each required intrinsically to fate hematopoietic stem cells (HSCs), just prior to their emergence from aortic hemogenic endothelium. PMID: 25230933
11. 90 % of proliferating radial glia express notch1a, notch1b and notch3. In contrast, the proliferating non-glial populations of the dorsal telencephalon and hypothalamus rarely express notch3 and about half express notch1a/1b. PMID: 24039926
12. entrainment of intracellular clocks by periodic activation of the Notch pathway is the mechanism maintaining cell synchrony during somitogenesis. PMID: 24715465
13. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch signaling PMID: 24309209
14. Ablation of xanthophores in yellow stripes induced melanophore death in black stripes, suggesting that melanophores require a survival signal from distant xanthophores. DeltaC and notch1a were expressed by xanthophores and melanophores, respectively. PMID: 24306107
15. Notch signalling maintains blastema cells in a plastic, undifferentiated and proliferative state, an essential requirement for fin regeneration. PMID: 23344707
16. Notch signaling activity maintains blastemal cells in a proliferative state and thus coordinates proliferation with differentiation during regenerative growth. PMID: 23462472
17. knockdown of Notch1a is sufficient to rescue both the proliferative and differentiation defects in Id2a-deficient retinae PMID: 22981606
18. A master role for Notch signaling in vertebrate mast cell development which establishes developmental origins of this lineage. PMID: 22368273
19. her8a is positively regulated by Su(H)-dependent Notch signaling as revealed by a Notch-defective mutant and injection of variants of the Notch intracellular regulator, Su(H). PMID: 21541299
20. Data show that inhibition or targeted knockdown of Notch signaling significantly increased clusterin mRNA expression in choroid plexus. PMID: 21385939
21. Data show that the d-Asb11 cullin box is required for both canonical Notch signaling and proper neurogenesis. PMID: 21124961
22. notch has a role in zebrafish intrahepatic biliary development PMID: 20108354
23. Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions PMID: 20573700
24. NLK negatively regulates Notch-dependent transcriptional activation by phosphorylating Notch1ICD. Phosphorylated Notch1ICD is impaired in its ability to form a transcriptionally active ternary complex. PMID: 20118921
25. mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalization; mib is essential for efficient activation of Notch signaling by Delta PMID: 12530964
26. Results suggest that Delta/D-Notch 1a signaling is required for spinal cord oligodendrocyte specification. PMID: 12835391
27. role for the Notch signaling pathway in the activation of the heart regenerative response PMID: 12909711
28. Mutations in the zebrafish deadly seven/notch1a (des) gene result in supernumerary Mauthner cells and demonstrate plasticity in the formation of the escape-response circuit PMID: 12954879
29. Notch activation couples the regulation of location and differentiation in hindbrain boundary cells. Such coupling may be important for these cells to act as a stable signaling center. PMID: 15068793
30. Notch has a role in inhibiting Ptf1 function and acinar cell differentiation PMID: 15280211
31. gli2b expression is affected in Hedgehog and Notch signaling related mutants during zebrafish embryonic development PMID: 15614761
32. Muller glia failed to differentiate suggesting an instructive role for Notch-Delta signaling in gliogenesis. PMID: 15680358
33. DeltaD-Notch signalling has a role in establishing the secretory fate in the zebrafish intestine PMID: 15689380
34. Data suggest that delta/notch- and integrinalpha5-dependent cell polarization and fibronectin matrix assembly occur concomitantly and interdependently during border morphogenesis. PMID: 15809039
35. during late embryogenesis, neural cells that have low but functional levels of Cdkn1c, regulated by Notch activity, are specified for oligodendrocyte fate PMID: 16033893
36. Together, our results indicate that Notch signaling regulates allocation of appropriate numbers of different midline cells by different mechanisms. PMID: 16876779
37. Notch signaling has a role in regulating neural precursor allocation and binary neuronal fate decisions in zebrafish PMID: 17442701
38. Notch1 transcription and activity was severely reduced in zebrafish and mouse Notch pathway mutants, suggesting that vertebrate Notch1 expression is regulated by a positive feedback loop PMID: 17685488
39. Notch signaling is continuously required during embryogenesis to maintain radial glia, limit motor neuron formation and permit oligodendrocyte development PMID: 18627107
40. d-Asb11 is a component in the regulation of Delta-Notch signalling, important in fine-tuning the lateral inhibition gradients between DeltaA and Notch through a cell non-autonomous mechanism. PMID: 18776899
41. knockdown of notch3 function in notch1a mutants leads to the loss of rhombomere boundary cells and causes neuronal hyperplasia PMID: 19705151

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KEGG: dre:30718

STRING: 7955.ENSDARP00000046632

UniGene: Dr.137595