Recombinant Rat Small conductance calcium-activated potassium channel protein 1 (Kcnn1)

Code CSB-CF012083RA
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Source in vitro E.coli expression system
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Product Details

Target Names
Kcnn1
Uniprot No.
Alternative Names
Kcnn1; Sk1; Small conductance calcium-activated potassium channel protein 1; SK1; SKCa 1; SKCa1; KCa2.1
Species
Rattus norvegicus (Rat)
Expression Region
1-536
Target Protein Sequence
MSSRSHNGSVGRPLGSGPGFLGWEPVDPEAGRPRQPTQGPGLQMMAKGQPAGLSPSGPRGHSQAQEEEEEEEDEDRPGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWERVSLISLELAVCAIHPVPGHYRFTWTARLAFSLVPSAAEADVDVLLSIPMFLRLYLLARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSISSWIVAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQSRVRKHQRKFLQAIHQAQKLRTVKIEQGKVNDQANTLADLAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPSLIAQAICPLPPPWPGPSHLTTAAQSPQSHWLPTTASDCG
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.
Gene References into Functions
  1. SK channel current is a substantial element in sustaining the substantia nigra pars compacta dopaminergic neuroal rhythmic pacemaking. PMID: 24841382
  2. This study demonistrated that SK1 and SK2 transcripts showed strong expression starting from E15 in the striatum and decreased throughout pre- and postnatal development. PMID: 24096910
  3. Small conductance Ca(2+)-activated K(+) (SK) channels expressed in the hypothalamic paraventricular nucleus play an important role in the regulation of sympathetic outflow and cardiovascular function. PMID: 22647293
  4. expressed in myometrium throughout pregnancy and contribute to outward current, regulate membrane potential and calcium signalling PMID: 19969350
  5. rSK1 subunit is synthesized in cells but does not form functional homomeric channels PMID: 14761961
  6. These results implicate SK1 subunits as key regulators of excitability and endocrine function in beta cells. PMID: 19101546
  7. downregulation of SK1 and SK3 channels and upregulation of SK2 channels provide direct evidence that these Ca2+-activated K+ channels play important roles in inferior colliculi neuronal hyperexcitability that leads to inherited seizure susceptibility PMID: 19254702

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Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Potassium channel KCNN family, KCa2.1/KCNN1 subfamily
Tissue Specificity
Widely expressed including brain.
Database Links
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