CDC55 Antibody

Code CSB-PA946916XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) CDC55 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
CDC55 antibody; YGL190C antibody; G1345 antibody; Protein phosphatase PP2A regulatory subunit B antibody; Cell division control protein 55 antibody; PR55 antibody
Raised in
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) CDC55 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.
Gene References into Functions
  1. CDC55 role in the regulation pericentric cohesin and anaphase onset. PMID: 29561844
  2. Cdc55 is required for reductional chromosome segregation during achiasmate meiosis. PMID: 27455870
  3. Results show that the phosphatase PP2ACdc55 counteracts and thereby delays cell-cycle phosphorylation by cyclin-dependent kinase specifically on threonine, but not serine, phosphorylation sites. PMID: 28132839
  4. orchestrated action of PP2A antagonizes Atg13 phosphorylation and promotes autophagy after the inactivation of TORC1 PMID: 27973551
  5. The PP2A(Cdc55) specifies Rho1 signaling output and that reciprocal antagonism between Rho1-PP2A(Cdc55) and Rho1-Pkc1 explains how only one signaling pathway is robustly activated at a time. PMID: 26728856
  6. we propose a clear picture of how PP2A(Cdc55) functions affect the regulation of various MEN components, contributing to mitotic exit. PMID: 24339788
  7. Identification of the adenovirus E4orf4 protein binding site on the B55alpha and Cdc55 regulatory subunits of PP2A: Implications for PP2A PMID: 24244166
  8. PP2A(Cdc55) regulates G1 cyclin stability. PMID: 23518505
  9. Methionine and S-adenosylmethionine levels represent a critical gauge of amino acid availability that is sensed via the methylation of PP2A to reciprocally regulate cell growth and autophagy. PMID: 23870128
  10. Cdc55 phosphatase is not involved in cytosolic stress signal perception but is involved in a specific intranuclear mechanism to regulate Msn2 and Msn4 nuclear accumulation and chromatin association under stress conditions. PMID: 23275436
  11. Separase acts directly on Scc1 and also indirectly, through inhibition of PP2A(Cdc55), to stimulate cohesin cleavage, providing a feedforward loop that may contribute to a robust and timely anaphase. PMID: 22814605
  12. A PP2A (Cdc) containing the human B/55 family B subunit ortholog Cdc55 is required for progression hrough meiosis I. PMID: 21455032
  13. Cdc55p/Zds2p module has a function in the regulation of the Swe1p-dependent G2/M checkpoint. PMID: 20980617
  14. residual phosphatase activity associated with Cdc55 in the absence of Tpd3 is sufficient to maintain a partially active spindle checkpoint and to prevent cytokinesis defects PMID: 15347656
  15. Ynd1p and Cdc55p share a common downstream target whose balanced modulation by the two E4orf4 partners is crucial to viability PMID: 16227198
  16. Cdc55 is an inhibitor of the exit from mitosis that contributes to mitotic arrest by preventing premature release of Cdc14 from the nucleolus independently of the known spindle checkpoint pathways. PMID: 16314395
  17. Results show that PP2A(Cdc55) phosphatase keeps Net1 underphosphorylated in metaphase, and that separase interacts with and downregulates PP2A(Cdc55), thereby facilitating Cdk-dependent Net1 phosphorylation. PMID: 16713564
  18. A novel mechanism for controlling sister chromatid severing and segregation involves Cdc55-regulated release of cohesion. PMID: 17502422
  19. Cdc55 is a separase inhibitor that is activated by Sgo1 when sister chromatids are not under tension. PMID: 19299562

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Protein Families
Phosphatase 2A regulatory subunit B family
Database Links

KEGG: sce:YGL190C

STRING: 4932.YGL190C

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