apl-1 Antibody

1. Data indicate that APL1-D2 binds Cu(I) and Cu(II) too weakly to sustain catalysis which suggests that it plays no significant role in copper handling in C. elegans. PMID: 24276282
2. present hypothetical models as to how sAPL-1 signaling influences metabolic and developmental pathways. PMID: 23044509
3. [review] Either loss or overexpression of APL-1 will result in lethality, demonstrating the importance of maintaining APL-1 within homeostatic levels, particularly within neurons. PMID: 22038715
4. Pan-neuronal expression of APL-1, the Caenorhabditis elegans ortholog of APP, disrupts several behaviors, such as olfactory and gustatory learning behavior and touch habituation. PMID: 22836251
5. signaling of the released APL-1 fragment modulates multiple metabolic states and that APL-1 is required throughout development. PMID: 22466039
6. Cholesterol and lrp-1 are involved in the regulation of synaptic transmission, similar to apl-1. PMID: 22363792
7. a critical cis-regulatory element of apl-1 transcription PMID: 21150118
8. Loss of apl-1 leads to neurotransmission defects. PMID: 20862215
9. the x-ray structure of the E2 domain of APL-1 PMID: 19906646
10. The 5' UTR of the Aplp1 gene lacks any type of CAGA box. PMID: 15208260
11. APL-1 acts non-cell-autonomously during development. PMID: 17267616
12. apl-1 expression is upregulated during the last larval stage in hypodermal seam cells which is transcriptionally regulated by hbl-1, lin-41 and lin-42. PMID: 18262516

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KEGG: cel:CELE_C42D8.8

STRING: 6239.C42D8.8a.2

UniGene: Cel.6164