nAChRalpha1 Antibody

Code CSB-PA267273XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) nAChRalpha1 Polyclonal antibody
Uniprot No.
Target Names
nAChRalpha1
Alternative Names
nAChRalpha1 antibody; Acr96Aa antibody; AcrB antibody; als antibody; nAcRalpha-96Aa antibody; CG5610 antibody; Acetylcholine receptor subunit alpha-like 1 antibody; Nicotinic acetylcholine receptor alpha 1 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) nAChRalpha1 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Gene References into Functions
  1. Study demonstrated several roles of the Dalpha1 nAChR subunit it is the target of the neonicotinoid class of insecticides and also uncovered roles for the gene in influencing mating behavior, patterns of sleep and life span. PMID: 29095106
  2. mutation can confer nitenpyram resistance PMID: 18405830
Subcellular Location
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein Families
Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily
Tissue Specificity
CNS in embryos.
Database Links

KEGG: dme:Dmel_CG5610

STRING: 7227.FBpp0303342

UniGene: Dm.2364

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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