acr-23 Antibody

Code CSB-PA185846XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans acr-23 Polyclonal antibody
Uniprot No.
Target Names
acr-23
Alternative Names
acr-23 antibody; 5E130 antibody; F59B1.9 antibody; Betaine receptor acr-23 antibody; Acetylcholine receptor subunit alpha-type acr-23 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans acr-23 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Betaine receptor that functions as a ligand-gated non-selective monovalent cation channel in mechanosensory neurons to maintain basal levels of locomotion. The channel is permeable to Na(+) and K(+) but not to Ba(2+) or Ca(2+) ions. Elicits current in response to betaine, very weak current in response to choline, virtually no current in response to acetylcholine and nicotine, and no current in response to glycine and GABA.
Gene References into Functions
  1. acr-23 Encodes a monepantel-sensitive channel in Caenorhabditis elegans. PMID: 23950710
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily
Tissue Specificity
Expressed in the body wall muscles that are arranged into four longitudinal bundles, some mechanosensory neurons, the head muscles and multiple interneurons. Not expressed in motor neurons (at protein level).
Database Links

STRING: 6239.F59B1.9

UniGene: Cel.9478

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