acn-1 Antibody

Code CSB-PA615120XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans acn-1 Polyclonal antibody
Uniprot No.
Target Names
acn-1
Alternative Names
acn-1 antibody; C42D8.5Inactive angiotensin-converting enzyme-related protein antibody; ACE-like non-metallopeptidase protein 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans acn-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related degenerative changes like reduced pharyngeal pumping and decreased body movements. Lifespan restriction is dependent on the forkhead-type transcription factor daf-16.
Gene References into Functions
  1. acn-1 genetically interacts with the let-7 microRNA and other heterochronic genes during C. elegans development. PMID: 28933985
  2. Acn-1 is a gene that influences C. elegans aging and life span. PMID: 26918946
  3. ACN-1 has an essential role in molting and morphogenesis of Caenorhabditis elegans PMID: 14559923
Protein Families
Peptidase M2 family
Tissue Specificity
Expressed in the hypodermis, in the vulva during organogenesis, and in the ray papillae of the male tail.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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