ACO1 Antibody

Code CSB-PA553972XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ACO1 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
ACO1 antibody; GLU1 antibody; YLR304C antibody; L8003.22Aconitate hydratase antibody; mitochondrial antibody; Aconitase antibody; EC antibody; Citrate hydro-lyase antibody
Raised in
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ACO1 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate, a step in the citric acid cycle. Can also provide minor contributions to the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. Plays also an essential role in mtDNA maintenance. May directly protect mtDNA from accumulation of point mutations and ssDNA breaks as a component of mitochondrial nucleoids, or by preventing accumulation of iron citrate thereby alleviating its detrimental effects in mitochondria.
Gene References into Functions
  1. Lack of the ACO1 gene results in increased zinc tolerance. PMID: 24503898
  2. frataxin is an iron chaperone protein that protects the aconitase [4Fe-4S]2+ cluster from disassembly and promotes enzyme reactivation PMID: 15247478
  3. essential for mtDNA maintenance independent of its catalytic activity; may integrate metabolic signals and mtDNA maintenance PMID: 15692048
  4. Yeast aconitase isoenzymes distribute between two distinct subcellular compartments and participate in two separate metabolic pathways: the glyoxylate shunt in the cytosol and the tricarboxylic acid cycle in mitochondria. PMID: 15975908
  5. mitochondria are opportunistic organelles that seize proteins, such as metabolic enzymes, for construction of the nucleoid, an mitochondrial DNA maintenance/segregation apparatus PMID: 17698960

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Subcellular Location
Mitochondrion. Cytoplasm. Note=Mainly mitochondrial, small amounts are also detected in the cytosol with a ratio of 94:6.
Protein Families
Aconitase/IPM isomerase family
Database Links

KEGG: sce:YLR304C

STRING: 4932.YLR304C

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