Acot1 Antibody

Code CSB-PA001163XA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Acot1 Polyclonal antibody
Uniprot No.
Target Names
Acot1
Alternative Names
Acot1 antibody; Cte1Acyl-coenzyme A thioesterase 1 antibody; Acyl-CoA thioesterase 1 antibody; EC 3.1.2.- antibody; CTE-I antibody; Inducible cytosolic acyl-coenzyme A thioester hydrolase antibody; LACH2 antibody; ACH2 antibody; Long chain acyl-CoA thioester hydrolase antibody; Long chain acyl-CoA hydrolase antibody; Palmitoyl-coenzyme A thioesterase antibody; EC 3.1.2.2 antibody
Raised in
Rabbit
Species Reactivity
Rattus norvegicus (Rat)
Immunogen
Recombinant Rattus norvegicus (Rat) Acot1 protein
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20).
Gene References into Functions
  1. The Acot1 expression is transiently upregulated at an early stage of adipocyte maturation, possibly to maintain cytosolic acyl-CoAs below a certain level until the cells acquire their full capability for fat storage. PMID: 23385637
  2. ACOT1 plays a crucial protective role in the diabetic heart via PPARalpha/PGC1alpha signaling. PMID: 23226270
  3. ACOT isoform expression may be regulated during brown adipocyte differentiation to support the fat storage and combustion characteristics of this cell type. PMID: 21094633
Subcellular Location
Cytoplasm, cytosol.
Protein Families
C/M/P thioester hydrolase family
Tissue Specificity
Expressed in liver.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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